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Steap4 Gene Detail
Summary
  • Symbol
    Steap4
  • Name
    STEAP family member 4
  • Synonyms
    1110021O17Rik, Tiarp, Tnfaip9
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923560
    NCBI Gene: 117167
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:8010472-8032213 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 3.37 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    667 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923560
 protein coding gene Chr5:8010457-8032213 (+)
129S1/SvImJ ENSMUSG00200001733
 protein coding gene Chr5:4708863-4728717 (+)
A/J ENSMUSG00195012211
 protein coding gene Chr5:4714183-4735941 (+)
AKR/J ENSMUSG00220001841
 protein coding gene Chr5:4621146-4641001 (+)
BALB/cJ ENSMUSG00180015392
 protein coding gene Chr5:4471544-4491583 (+)
C3H/HeJ ENSMUSG00175027745
 protein coding gene Chr5:4645052-4666808 (+)
C57BL/6NJ ENSMUSG00215011714
 protein coding gene Chr5:4926655-4948412 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026953
 protein coding gene Chr5:4602079-4623816 (+)
CAST/EiJ ENSTCUG00005001295
 protein coding gene Chr5:4815897-4836001 (+)
CBA/J ENSMUSG00210002200
 protein coding gene Chr5:5015581-5037338 (+)
DBA/2J ENSMUSG00185027527
 protein coding gene Chr5:5013478-5035235 (+)
FVB/NJ ENSMUSG00205007192
 protein coding gene Chr5:4729039-4749077 (+)
JF1/MsJ ENSUMUG00000001737
 protein coding gene Chr5:5058410-5080082 (+)
LP/J ENSMUSG00230002885
 protein coding gene Chr5:8956497-8976349 (+)
NOD/ShiLtJ ENSMUSG00190011711
 protein coding gene Chr5:4536219-4557887 (+)
NZO/HlLtJ ENSMUSG00225008265
 protein coding gene Chr5:12691845-12711695 (+)
PWK/PhJ ENSLUMG00010019290
 protein coding gene Chr5:4964700-4986104 (+)
SPRET/EiJ ENSMSPG00010004974
 protein coding gene Chr5:4856027-4877699 (+)
WSB/EiJ ENSIUOG00005026023
 protein coding gene Chr5:4724741-4744585 (+)



Homology
more
  • Human Ortholog
    STEAP4, STEAP4 metalloreductase
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    STEAP4, STEAP4 metalloreductase
  • Synonyms
    SchLAH, STAMP2, TIARP, TNFAIP9
  • Links
    NCBI Gene ID: 79689
    UniProt: Q687X5

  • Chr Location
    7q21.12; chr7:88270892-88307010 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 1 allele in 1 genetic background
    3 phenotypes from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit adipose accumulation, oxidative stress, increased liver weight, lower metabolic rate, hypoactivity, insulin resistance, glucose intolerance, mild hyperglycemia and dyslipidemia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    42
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    604
  • Tissues
    5
  • cDNA Data
    41
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 117167 NCBI Gene Model | MGI Sequence Detail 21742 C57BL/6J ±  kb
    transcript NM_054098 RefSeq | MGI Sequence Detail 3159 C57BL/6  
    polypeptide Q923B6 UniProt | EBI | MGI Sequence Detail 470 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 41
      cDNA 41

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2140915, MGI:2152335
    References
    more
    • Summaries
      All 54
      Developmental Gene Expression 2
      Gene Ontology 10
      Phenotypes 12
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:367683 Yin K, et al., The STEAP4 target NQO1 mediates colon tumorigenesis. J Cell Sci. 2025 May 15;138(10)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory