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Dnttip1 Gene Detail
Summary
  • Symbol
    Dnttip1
  • Name
    deoxynucleotidyltransferase, terminal, interacting protein 1
  • Synonyms
    6430706C13Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923483
    NCBI Gene: 76233
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:164587935-164610140 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 85.27 cM, cytoband H3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    475 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923483
 protein coding gene Chr2:164587903-164610527 (+)
129S1/SvImJ ENSMUSG00200016792
 protein coding gene Chr2:161476969-161499616 (+)
A/J ENSMUSG00195023786
 protein coding gene Chr2:161809015-161831637 (+)
AKR/J ENSMUSG00220013083
 protein coding gene Chr2:161138466-161161089 (+)
BALB/cJ ENSMUSG00180048147
 protein coding gene Chr2:161262725-161285348 (+)
C3H/HeJ ENSMUSG00175048750
 protein coding gene Chr2:162013287-162035951 (+)
C57BL/6NJ ENSMUSG00215027500
 protein coding gene Chr2:161460800-161483427 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024664
 protein coding gene Chr2:156691991-156713549 (+)
CAST/EiJ ENSTCUG00005045048
 protein coding gene Chr2:160380137-160402903 (+)
CBA/J ENSMUSG00210015917
 protein coding gene Chr2:161943382-161966004 (+)
DBA/2J ENSMUSG00185044712
 protein coding gene Chr2:161680439-161703099 (+)
FVB/NJ ENSMUSG00205026401
 protein coding gene Chr2:160701316-160723968 (+)
JF1/MsJ ENSUMUG00000029399
 protein coding gene Chr2:161320640-161343196 (+)
LP/J ENSMUSG00230039634
 protein coding gene Chr2:163238067-163260714 (+)
NOD/ShiLtJ ENSMUSG00190028351
 protein coding gene Chr2:161348236-161370858 (+)
NZO/HlLtJ ENSMUSG00225050805
 protein coding gene Chr2:171242766-171265427 (+)
PWK/PhJ ENSLUMG00010045885
 protein coding gene Chr2:161223372-161245931 (+)
SPRET/EiJ ENSMSPG00010025729
 protein coding gene Chr2:163986079-164006039 (+)
WSB/EiJ ENSIUOG00005042807
 protein coding gene Chr2:161069272-161091893 (+)



Homology
more
  • Human Ortholog
    DNTTIP1, deoxynucleotidyltransferase terminal interacting protein 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DNTTIP1, deoxynucleotidyltransferase terminal interacting protein 1
  • Synonyms
    C20orf167, dJ447F3.4, Tdif1
  • Links
    NCBI Gene ID: 116092
    UniProt: Q9H147

  • Chr Location
    20q13.12; chr20:45791946-45811427 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 2 alleles in 2 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous knockout affects mitosis and hematopoiesis (embryos lack red blood cells) and is embryonic lethal.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    647
  • Tissues
    43
  • cDNA Data
    75
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 76233 NCBI Gene Model | MGI Sequence Detail 22206 C57BL/6J ±  kb
    transcript NM_133763 RefSeq | MGI Sequence Detail 1257 Not Specified  
    polypeptide Q99LB0 UniProt | EBI | MGI Sequence Detail 328 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 75
      cDNA 75

      Microarray probesets 4
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 3
      Gene Ontology 7
      Phenotypes 13
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:390652 Bao K, et al., A di-acetyl-decorated chromatin signature couples liquid condensation to suppress DNA end synapsis. Mol Cell. 2024 Feb 21;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory