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Tlcd4 Gene Detail
Summary
  • Symbol
    Tlcd4
  • Name
    TLC domain containing 4
  • Synonyms
    4930577M16Rik, C730036B01Rik, Tmem56
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923195
    NCBI Gene: 99887
  • Alliance
    genome feature page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:120995657-121076756 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 52.94 cM, cytoband G3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2484 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923195
 protein coding gene Chr3:120995410-121076756 (-)
129S1/SvImJ ENSMUSG00200026116
 protein coding gene Chr3:117677040-117758602 (-)
A/J ENSMUSG00195014362
 protein coding gene Chr3:117896671-117978087 (-)
AKR/J ENSMUSG00220025197
 protein coding gene Chr3:116288642-116370059 (-)
BALB/cJ ENSMUSG00180029412
 protein coding gene Chr3:117832929-117914336 (-)
C3H/HeJ ENSMUSG00175025278
 protein coding gene Chr3:117380062-117461479 (-)
C57BL/6NJ ENSMUSG00215006153
 protein coding gene Chr3:118128551-118209943 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025583
 protein coding gene Chr3:114709390-114786935 (-)
CAST/EiJ ENSTCUG00005031460
 protein coding gene Chr3:118375958-118457510 (-)
CBA/J ENSMUSG00210002874
 protein coding gene Chr3:118011034-118092445 (-)
DBA/2J ENSMUSG00185007306
 protein coding gene Chr3:118583284-118665264 (-)
FVB/NJ ENSMUSG00205007053
 protein coding gene Chr3:116952579-117033988 (-)
JF1/MsJ ENSUMUG00000001692
 protein coding gene Chr3:117463403-117545381 (-)
LP/J ENSMUSG00230010160
 protein coding gene Chr3:120527730-120609284 (-)
NOD/ShiLtJ ENSMUSG00190025849
 protein coding gene Chr3:118963828-119045249 (-)
NZO/HlLtJ ENSMUSG00225002144
 protein coding gene Chr3:123022713-123104122 (-)
PWK/PhJ ENSLUMG00010009049
 protein coding gene Chr3:117370272-117452428 (-)
SPRET/EiJ ENSMSPG00010026994
 protein coding gene Chr3:118099391-118179761 (-)
WSB/EiJ ENSIUOG00005006537
 protein coding gene Chr3:118176638-118257977 (-)



Homology
more
  • Human Ortholog
    TLCD4, TLC domain containing 4
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TLCD4, TLC domain containing 4
  • Synonyms
    TMEM56
  • Links
    NCBI Gene ID: 148534
    UniProt: Q96MV1

  • Chr Location
    1p21.3; chr1:95092517-95197607 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    13 phenotype references
  • All Mutations and Alleles
    11
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    4
  • Gene trapped
    1
  • Radiation induced
    1
  • Targeted
    4
  • Genomic Mutations
    2 involving Tlcd4
  • Find Mice (IMSR)
    20 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    5
  • GO References
    4
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    693
  • Tissues
    47
  • cDNA Data
    14
  • Literature Summary
    4
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 99887 NCBI Gene Model | MGI Sequence Detail 81100 C57BL/6J ±  kb
transcript NM_001355678 RefSeq | MGI Sequence Detail 6549 C57BL/6  
polypeptide Q8CGF5 UniProt | EBI | MGI Sequence Detail 276 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 16
    cDNA 14
    Primer pair 2
    Antibodies 1

    Microarray probesets 9
Other
Accession IDs
less
MGI:2139869, MGI:2139968, MGI:6369423
References
more
  • Summaries
    All 45
    Developmental Gene Expression 4
    Diseases 1
    Gene Ontology 4
    Phenotypes 13
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:385397 Dorschner B, et al., TRAM-LAG1-CLN8 domain-containing protein TMEM56 regulates cell migration by changing intracellular ceramide levels. BMC Biol. 2026 May 5;24(1)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory