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Mapda Gene Detail
Summary
  • Symbol
    Mapda
  • Name
    N6-Methyl-AMP deaminase
  • Synonyms
    4930578F03Rik, Adal
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923144
    NCBI Gene: 75894
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:120970909-120987161 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 60.37 cM, cytoband F1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    374 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923144
 protein coding gene Chr2:120970525-120989921 (+)
129S1/SvImJ ENSMUSG00200046897
 protein coding gene Chr2:117902586-117918995 (+)
A/J ENSMUSG00195024469
 protein coding gene Chr2:117944121-117960502 (+)
AKR/J ENSMUSG00220037337
 protein coding gene Chr2:117866916-117883316 (+)
BALB/cJ ENSMUSG00180042169
 protein coding gene Chr2:117744743-117761124 (+)
C3H/HeJ ENSMUSG00175023436
 protein coding gene Chr2:118218898-118235267 (+)
C57BL/6NJ ENSMUSG00215013155
 protein coding gene Chr2:117889241-117905490 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024183
 protein coding gene Chr2:113994276-114012126 (+)
CAST/EiJ ENSTCUG00005016841
 protein coding gene Chr2:117153965-117170357 (+)
CBA/J ENSMUSG00210007036
 protein coding gene Chr2:118059793-118076156 (+)
DBA/2J ENSMUSG00185045900
 protein coding gene Chr2:117742079-117758460 (+)
FVB/NJ ENSMUSG00205018991
 protein coding gene Chr2:116967566-116983967 (+)
JF1/MsJ ENSUMUG00000035701
 protein coding gene Chr2:117637451-117653699 (+)
LP/J ENSMUSG00230021421
 protein coding gene Chr2:119562057-119581571 (+)
NOD/ShiLtJ ENSMUSG00190041753
 protein coding gene Chr2:117988029-118004443 (+)
NZO/HlLtJ ENSMUSG00225003968
 protein coding gene Chr2:127466283-127485756 (+)
PWK/PhJ ENSLUMG00010043725
 protein coding gene Chr2:117529811-117546060 (+)
SPRET/EiJ ENSMSPG00010037862
 protein coding gene Chr2:119968723-119990346 (+)
WSB/EiJ ENSIUOG00005024755
 protein coding gene Chr2:117715632-117732009 (+)



Homology
more
  • Human Ortholog
    MAPDA, N6-Methyl-AMP deaminase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MAPDA, N6-Methyl-AMP deaminase
  • Synonyms
    ADAL, HsMAPDA
  • Links
    NCBI Gene ID: 161823
    UniProt: Q6DHV7

  • Chr Location
    15q15.3; chr15:43330307-43355418 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    55
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000027259 Ensembl Gene Model | MGI Sequence Detail 16253 C57BL/6J ±  kb
transcript ENSMUST00000119031 Ensembl | MGI Sequence Detail 2477 Not Applicable  
polypeptide ENSMUSP00000113052 Ensembl | MGI Sequence Detail 360 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 55
    cDNA 55

    Microarray probesets 5
Other
Accession IDs
less
MGI:8330063
References
more
  • Summaries
    All 43
    Gene Ontology 9
    Phenotypes 12
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:376103 Ogawa A, et al., Adenosine kinase and ADAL coordinate detoxification of modified adenosines to safeguard metabolism. Cell. 2025 Oct 30;188(22):6151-6169.e24
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory