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Fam227a Gene Detail
Summary
  • Symbol
    Fam227a
  • Name
    family with sequence similarity 227, member A
  • Synonyms
    4933432B09Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1922979
    NCBI Gene: 75729
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:79496518-79543157 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 37.81 cM, cytoband E2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1373 from dbSNP Build 142
  • Strain Annotations
    23
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1922979
 protein coding gene Chr15:79493777-79543157 (-)
129S1/SvImJ ENSMUSGG00200054964
 protein coding gene Chr15:76616453-76634254 (-)
129S1/SvImJ ENSMUSG00200052476
 protein coding gene Chr15:76646254-76654017 (-)
A/J ENSMUSG00195045039
 protein coding gene Chr15:76556601-76605852 (-)
AKR/J ENSMUSG00220049074
 protein coding gene Chr15:76632586-76640345 (-)
AKR/J ENSMUSGG00220054304
 protein coding gene Chr15:76602803-76620588 (-)
BALB/cJ ENSMUSG00180047973
 protein coding gene Chr15:76433589-76482848 (-)
C3H/HeJ ENSMUSG00175048583
 protein coding gene Chr15:76744829-76794078 (-)
C57BL/6NJ ENSMUSGG00215055811
 protein coding gene Chr15:76507005-76524753 (-)
C57BL/6NJ ENSMUSG00215050789
 protein coding gene Chr15:76536749-76544496 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020019
 protein coding gene Chr15:73614289-73663465 (-)
CAST/EiJ no annotation
CBA/J ENSMUSG00210040679
 protein coding gene Chr15:76552541-76560298 (-)
CBA/J ENSMUSGG00210055078
 protein coding gene Chr15:76522754-76540545 (-)
DBA/2J ENSMUSG00185049391
 protein coding gene Chr15:76529828-76579078 (-)
FVB/NJ ENSMUSG00205048740
 protein coding gene Chr15:76289737-76297492 (-)
FVB/NJ ENSMUSGG00205054659
 protein coding gene Chr15:76259955-76277742 (-)
JF1/MsJ no annotation
LP/J ENSMUSGG00230055890
 protein coding gene Chr15:79864890-79882686 (-)
LP/J ENSMUSG00230052518
 protein coding gene Chr15:79894687-79902451 (-)
NOD/ShiLtJ ENSMUSG00190048314
 protein coding gene Chr15:76539581-76589060 (-)
NZO/HlLtJ ENSMUSGG00225055154
 protein coding gene Chr15:80187778-80205541 (-)
PWK/PhJ ENSLUMG00010042549
 protein coding gene Chr15:76323578-76372558 (-)
SPRET/EiJ ENSMSPG00010044935
 protein coding gene Chr15:77986523-78036685 (-)
WSB/EiJ ENSIUOG00005045249
 protein coding gene Chr15:76589325-76638544 (-)



Homology
more
  • Human Ortholog
    FAM227A, family with sequence similarity 227 member A
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FAM227A, family with sequence similarity 227 member A
  • Links
    NCBI Gene ID: 646851
    UniProt: F5H4B4

  • Chr Location
    22q13.1; chr22:38578118-38656629 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    28 phenotype references
  • All Mutations and Alleles
    12
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    1
  • Gene trapped
    6
  • Radiation induced
    2
  • Targeted
    2
  • Genomic Mutations
    3 involving Fam227a
  • Incidental Mutations
    APF , CvDC
  • Find Mice (IMSR)
    59 strains or lines available
Gene Ontology
(GO)
Classifications
less
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    14
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000042564 Ensembl Gene Model | MGI Sequence Detail 46640 C57BL/6J ±  kb
transcript ENSMUST00000187519 Ensembl | MGI Sequence Detail 2283 Not Applicable  
polypeptide ENSMUSP00000139524 Ensembl | MGI Sequence Detail 625 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    7 Sequences
  • InterPro Domains
    IPR029417 FAM227 Protein
Molecular
Reagents
less
  • All nucleic 14
    cDNA 14

    Microarray probesets 2
References
more
  • Summaries
    All 45
    Diseases 1
    Phenotypes 28
  • Earliest
    J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
  • Latest
    J:387680 Ahn B, et al., Disorganization of Transcriptional Regulation and Alteration of Keratin Family Gene Expression in Hairy Ear Mice. Genes (Basel). 2026 Jan 31;17(2)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory