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Ttll8 Gene Detail
Summary
  • Symbol
    Ttll8
  • Name
    tubulin tyrosine ligase-like family, member 8
  • Synonyms
    1700019P01Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1922902
    NCBI Gene: 239591
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:88774836-88838621 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 44.39 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1552 from dbSNP Build 142
  • Strain Annotations
    14
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1922902
 protein coding gene Chr15:88773981-88839258 (-)
129S1/SvImJ ENSMUSG00200033126
 protein coding gene Chr15:85926725-85990508 (-)
A/J ENSMUSGG00195055152
 protein coding gene Chr15:85891539-85912131 (-)
AKR/J ENSMUSGG00220054606
 protein coding gene Chr15:85922134-85942717 (-)
BALB/cJ ENSMUSGG00180054999
 protein coding gene Chr15:85745383-85765974 (-)
C3H/HeJ ENSMUSGG00175054969
 protein coding gene Chr15:86078217-86098803 (-)
C57BL/6NJ ENSMUSGG00215055444
 protein coding gene Chr15:85838912-85859498 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020146
 protein coding gene Chr15:82846248-82911861 (-)
CAST/EiJ no annotation
CBA/J ENSMUSGG00210054804
 protein coding gene Chr15:85847680-85868264 (-)
DBA/2J ENSMUSGG00185057642
 protein coding gene Chr15:85859562-85880146 (-)
FVB/NJ ENSMUSGG00205054544
 protein coding gene Chr15:85621865-85642410 (-)
JF1/MsJ no annotation
LP/J ENSMUSGG00230055836
 protein coding gene Chr15:89210116-89230700 (-)
NOD/ShiLtJ no annotation
NZO/HlLtJ ENSMUSG00225048736
 protein coding gene Chr15:89483484-89547262 (-)
PWK/PhJ no annotation
SPRET/EiJ ENSMSPG00010013335
 protein coding gene Chr15:87266150-87307854 (-)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    TTLL8, tubulin tyrosine ligase like 8
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TTLL8, tubulin tyrosine ligase like 8
  • Links
    NCBI Gene ID: 164714
    UniProt: A6PVC2

  • Chr Location
    22q13.33; chr22:50018575-50058298 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from multigenic genotypes
    31 phenotype references
Mice homozygous for a null allele of Ttll8 and Ttll3 exhibit reduced male fertility associated with asthenozoospermia and kinked flagellum.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    6
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022388 Ensembl Gene Model | MGI Sequence Detail 63786 C57BL/6J ±  kb
transcript ENSMUST00000109371 Ensembl | MGI Sequence Detail 2968 Not Applicable  
polypeptide ENSMUSP00000104996 Ensembl | MGI Sequence Detail 832 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 6
    cDNA 6

    Microarray probesets 1
References
more
  • Summaries
    All 53
    Developmental Gene Expression 1
    Diseases 1
    Gene Ontology 8
    Phenotypes 31
  • Earliest
    J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
  • Latest
    J:387680 Ahn B, et al., Disorganization of Transcriptional Regulation and Alteration of Keratin Family Gene Expression in Hairy Ear Mice. Genes (Basel). 2026 Jan 31;17(2)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory