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Tm4sf5 Gene Detail
Summary
  • Symbol
    Tm4sf5
  • Name
    transmembrane 4 superfamily member 5
  • Synonyms
    2010003F10Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1922854
    NCBI Gene: 75604
  • Alliance
    genome feature page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:70396100-70402009 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 42.99 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    53 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1922854
 protein coding gene Chr11:70396070-70402009 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018598
 protein coding gene Chr11:71040137-71046069 (+)
A/J MGP_AJ_G0018566
 protein coding gene Chr11:68346103-68352037 (+)
AKR/J MGP_AKRJ_G0018535
 protein coding gene Chr11:70398805-70404734 (+)
BALB/cJ MGP_BALBcJ_G0018538
 protein coding gene Chr11:68666377-68672309 (+)
C3H/HeJ MGP_C3HHeJ_G0018351
 protein coding gene Chr11:70426945-70432936 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018989
 protein coding gene Chr11:73192572-73198506 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016634
 protein coding gene Chr11:65268714-65274698 (+)
CAST/EiJ MGP_CASTEiJ_G0017906
 protein coding gene Chr11:70675223-70681114 (+)
CBA/J MGP_CBAJ_G0018323
 protein coding gene Chr11:76471895-76477829 (+)
DBA/2J MGP_DBA2J_G0018433
 protein coding gene Chr11:67929721-67935645 (+)
FVB/NJ MGP_FVBNJ_G0018423
 protein coding gene Chr11:67574758-67580686 (+)
LP/J MGP_LPJ_G0018503
 protein coding gene Chr11:71612486-71620314 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018446
 protein coding gene Chr11:77045489-77053335 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019031
 protein coding gene Chr11:70660160-70666093 (+)
PWK/PhJ MGP_PWKPhJ_G0017680
 protein coding gene Chr11:68569613-68575573 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017470
 protein coding gene Chr11:70470640-70479263 (+)
WSB/EiJ MGP_WSBEiJ_G0017960
 protein coding gene Chr11:70322099-70328017 (+)



Homology
more
  • Human Ortholog
    TM4SF5, transmembrane 4 L six family member 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TM4SF5, transmembrane 4 L six family member 5
  • Links
    NCBI Gene ID: 9032
    UniProt: O14894

  • Chr Location
    17p13.2; chr17:4771849-4783213 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit lower RPS6KB1 activity in liver extracts.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    764
  • Tissues
    9
  • cDNA Data
    12
  • Literature Summary
    3
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 75604 NCBI Gene Model | MGI Sequence Detail 5910 C57BL/6J ±  kb
transcript NM_029360 RefSeq | MGI Sequence Detail 981 C57BL/6  
polypeptide NP_083636 RefSeq | MGI Sequence Detail 196 C57BL/6  
For the selected sequence
Protein
Information
less
  • UniProt
    3 Sequences
  • InterPro Domains
    IPR008661 L6 membrane
Molecular
Reagents
less
  • All nucleic 14
    cDNA 12
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
less
MGI:2144124
References
more
  • Summaries
    All 58
    Developmental Gene Expression 3
    Phenotypes 30
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
06/09/2026
MGI 6.24 		The Jackson Laboratory