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Ppp1r35 Gene Detail
Summary
  • Symbol
    Ppp1r35
  • Name
    protein phosphatase 1, regulatory subunit 35
  • Synonyms
    2010007H12Rik, 2010011D20Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1922853
    NCBI Gene: 69871
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:137777138-137778372 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 76.70 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    99 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1922853
 protein coding gene Chr5:137777111-137778372 (+)
129S1/SvImJ ENSMUSG00200046381
 protein coding gene Chr5:131573962-131575223 (+)
A/J ENSMUSG00195043745
 protein coding gene Chr5:131075337-131076598 (+)
AKR/J ENSMUSG00220048352
 protein coding gene Chr5:130551845-130553105 (+)
BALB/cJ ENSMUSG00180037627
 protein coding gene Chr5:131171921-131173182 (+)
C3H/HeJ ENSMUSG00175037345
 protein coding gene Chr5:133099406-133100667 (+)
C57BL/6NJ ENSMUSG00215045743
 protein coding gene Chr5:131220739-131222000 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027891
 protein coding gene Chr5:130586728-130587980 (+)
CAST/EiJ ENSTCUG00005009820
 protein coding gene Chr5:130442337-130443595 (+)
CBA/J ENSMUSG00210023429
 protein coding gene Chr5:131916973-131918234 (+)
DBA/2J ENSMUSG00185050058
 protein coding gene Chr5:134932328-134933589 (+)
FVB/NJ ENSMUSG00205048274
 protein coding gene Chr5:130816090-130817351 (+)
JF1/MsJ ENSUMUG00000031384
 protein coding gene Chr5:137828905-137830159 (+)
LP/J ENSMUSG00230040812
 protein coding gene Chr5:139045774-139047035 (+)
NOD/ShiLtJ ENSMUSG00190034420
 protein coding gene Chr5:130871607-130872868 (+)
NZO/HlLtJ ENSMUSG00225023088
 protein coding gene Chr5:146721926-146723187 (+)
PWK/PhJ ENSLUMG00010013763
 protein coding gene Chr5:129682669-129683921 (+)
SPRET/EiJ ENSMSPG00010035254
 protein coding gene Chr5:133077638-133078894 (+)
WSB/EiJ ENSIUOG00005033285
 protein coding gene Chr5:133523594-133524855 (+)



Homology
more
  • Human Ortholog
    PPP1R35, protein phosphatase 1 regulatory subunit 35
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PPP1R35, protein phosphatase 1 regulatory subunit 35
  • Synonyms
    C7orf47
  • Links
    NCBI Gene ID: 221908
    UniProt: Q8TAP8

  • Chr Location
    7q22.1; chr7:100435282-100436698 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    27 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    1 images
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele lack primary cilia and show embryonic growth retardation, failure of embryo turning, distended pericardium, open neural tube, increased neural tube cell death, abnormal notochord development, and complete embryonic lethality during organogenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    712
  • Tissues
    83
  • cDNA Data
    28
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 69871 NCBI Gene Model | MGI Sequence Detail 1235 C57BL/6J ±  kb
    transcript NM_027242 RefSeq | MGI Sequence Detail 953 C57BL/6  
    polypeptide Q9D8C8 UniProt | EBI | MGI Sequence Detail 260 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000031115 protein phosphatase 1 regulatory subunit 35
      (term hierarchy)
    • InterPro Domains
      IPR033590 Protein phosphatase 1 regulatory subunit 35
      IPR029135 Protein phosphatase 1 regulatory subunit 35, C-terminal
    Molecular
    Reagents
    less
    • All nucleic 31
      cDNA 29
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1917121, MGI:2141018
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 3
      Gene Ontology 7
      Phenotypes 10
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory