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Atf7ip2 Gene Detail
Summary
  • Symbol
    Atf7ip2
  • Name
    activating transcription factor 7 interacting protein 2
  • Synonyms
    4930558K11Rik, Get-1, MGC:6783, PSM2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1922579
    NCBI Gene: 75329
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:10010513-10068595 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 5.50 cM, cytoband A3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1171 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1922579
 protein coding gene Chr16:10010513-10069342 (+)
129S1/SvImJ ENSMUSG00200010839
 protein coding gene Chr16:7001752-7070158 (+)
A/J ENSMUSG00195011314
 protein coding gene Chr16:6555688-6614475 (+)
AKR/J ENSMUSG00220017051
 protein coding gene Chr16:6844489-6903275 (+)
BALB/cJ ENSMUSG00180008381
 protein coding gene Chr16:6794774-6853548 (+)
C3H/HeJ ENSMUSG00175025889
 protein coding gene Chr16:6985792-7044565 (+)
C57BL/6NJ ENSMUSG00215017415
 protein coding gene Chr16:6659966-6718743 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020439
 protein coding gene Chr16:6730100-6785422 (+)
CAST/EiJ ENSTCUG00005028296
 protein coding gene Chr16:6905364-6963913 (+)
CBA/J ENSMUSG00210011251
 protein coding gene Chr16:7003010-7061776 (+)
DBA/2J ENSMUSG00185009963
 protein coding gene Chr16:6948294-7007060 (+)
FVB/NJ ENSMUSG00205012045
 protein coding gene Chr16:6865052-6923820 (+)
JF1/MsJ ENSUMUG00000021115
 protein coding gene Chr16:7058014-7111749 (+)
LP/J ENSMUSG00230009640
 protein coding gene Chr16:9500283-9565934 (+)
NOD/ShiLtJ ENSMUSG00190023839
 protein coding gene Chr16:7047036-7105800 (+)
NZO/HlLtJ ENSMUSG00225031965
 protein coding gene Chr16:12731357-12790125 (+)
PWK/PhJ ENSLUMG00010016957
 protein coding gene Chr16:6887192-6946524 (+)
SPRET/EiJ ENSMSPG00010015822
 protein coding gene Chr16:6877952-6928515 (+)
WSB/EiJ ENSIUOG00005015340
 protein coding gene Chr16:6996255-7055153 (+)



Homology
more
  • Human Ortholog
    ATF7IP2, activating transcription factor 7 interacting protein 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ATF7IP2, activating transcription factor 7 interacting protein 2
  • Synonyms
    MCAF2
  • Links
    NCBI Gene ID: 80063
    UniProt: Q5U623

  • Chr Location
    16p13.2-p13.13; chr16:10326434-10483640 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null males are infertile, have small testes and are devoid of haploid spermatids. Spermatocytes do not progress beyond the pachytene-to-diplotene transition, with abnormal sex chromosome synapsis and autosomal asynapsis in some pachytene spermatocytes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    5
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    807
  • Tissues
    143
  • cDNA Data
    17
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 75329 NCBI Gene Model | MGI Sequence Detail 58083 C57BL/6J ±  kb
    transcript NM_153123 RefSeq | MGI Sequence Detail 2584 C57BL/6  
    polypeptide Q3UL97 UniProt | EBI | MGI Sequence Detail 452 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000004406 activating transcription factor 7-interacting protein 2
      (term hierarchy)
    • InterPro Domains
      IPR026085 Activating transcription factor 7-interacting protein
      IPR056565 Activating transcription factor 7-interacting protein, Fn3 domain
      IPR031870 ATF7-interacting protein , protein binding domain
      IPR003961 Fibronectin type III
      IPR036116 Fibronectin type III superfamily
      IPR013783 Immunoglobulin-like fold
    Molecular
    Reagents
    less
    • All nucleic 21
      cDNA 17
      Primer pair 2
      Other 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2385609
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 4
      Gene Ontology 2
      Phenotypes 8
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:360872 Alavattam KG, et al., ATF7IP2/MCAF2 directs H3K9 methylation and meiotic gene regulation in the male germline. Genes Dev. 2024 Mar 22;38(3-4):115-130
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory