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Timmdc1 Gene Detail
Summary
  • Symbol
    Timmdc1
  • Name
    translocase of inner mitochondrial membrane domain containing 1
  • Synonyms
    2810021C21Rik, 4930455C21Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1922139
    NCBI Gene: 76916
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:38318709-38343025 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 26.86 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1016 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1922139
 protein coding gene Chr16:38318205-38343075 (-)
129S1/SvImJ ENSMUSG00200028447
 protein coding gene Chr16:35255106-35280031 (-)
A/J ENSMUSG00195010223
 protein coding gene Chr16:34801072-34825396 (-)
AKR/J ENSMUSG00220026281
 protein coding gene Chr16:35179759-35212274 (-)
BALB/cJ ENSMUSG00180012554
 protein coding gene Chr16:35016538-35040864 (-)
C3H/HeJ ENSMUSG00175028182
 protein coding gene Chr16:35241979-35266289 (-)
C57BL/6NJ ENSMUSG00215010991
 protein coding gene Chr16:35090644-35114963 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020745
 protein coding gene Chr16:35570570-35596109 (-)
CAST/EiJ ENSTCUG00005029248
 protein coding gene Chr16:35547876-35572190 (-)
CBA/J ENSMUSG00210026308
 protein coding gene Chr16:35299093-35323403 (-)
DBA/2J ENSMUSG00185023964
 protein coding gene Chr16:35202041-35226354 (-)
FVB/NJ ENSMUSG00205017040
 protein coding gene Chr16:35177260-35201581 (-)
JF1/MsJ ENSUMUG00000027748
 protein coding gene Chr16:35446313-35471236 (-)
LP/J ENSMUSG00230025247
 protein coding gene Chr16:37774153-37798460 (-)
NOD/ShiLtJ ENSMUSG00190020581
 protein coding gene Chr16:35310940-35343456 (-)
NZO/HlLtJ ENSMUSG00225028820
 protein coding gene Chr16:40873541-40897851 (-)
PWK/PhJ ENSLUMG00010027392
 protein coding gene Chr16:35352743-35376978 (-)
SPRET/EiJ ENSMSPG00010015482
 protein coding gene Chr16:35307893-35332529 (-)
WSB/EiJ ENSIUOG00005025297
 protein coding gene Chr16:35406282-35430592 (-)



Homology
more
  • Human Ortholog
    TIMMDC1, translocase of inner mitochondrial membrane domain containing 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TIMMDC1, translocase of inner mitochondrial membrane domain containing 1
  • Synonyms
    C3orf1, MC1DN31
  • Links
    NCBI Gene ID: 51300
    UniProt: Q9NPL8

  • Chr Location
    3q13.33; chr3:119498515-119525090 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human TIMMDC1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele exhibit lethality. Heterozygous mice show an increased mean percentage of CD4 cells in the peripheral blood compared with controls, but no other notable heterozygous phenotype was detected.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    6
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    17
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000002846 Ensembl Gene Model | MGI Sequence Detail 24317 C57BL/6J ±  kb
    transcript ENSMUST00000002925 Ensembl | MGI Sequence Detail 1573 Not Applicable  
    polypeptide ENSMUSP00000002925 Ensembl | MGI Sequence Detail 285 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000031702 complex I assembly factor TIMMDC1, mitochondrial
      (term hierarchy)
    • InterPro Domains
      IPR055299 Complex I assembly factor TIMMDC1
    • GlyGen
      Q8BUY5 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 18

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1924166, MGI:2146599
    References
    more
    • Summaries
      All 44
      Gene Ontology 6
      Phenotypes 14
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory