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Ppa2 Gene Detail
Summary
  • Symbol
    Ppa2
  • Name
    pyrophosphatase (inorganic) 2
  • Synonyms
    1110013G13Rik, Sid6306
  • Feature Type
    protein coding gene
  • IDs
    MGI:1922026
    NCBI Gene: 74776
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:133015871-133083996 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 61.71 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    2199 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1922026
 protein coding gene Chr3:133015842-133083996 (+)
129S1/SvImJ ENSMUSG00200003474
 protein coding gene Chr3:129786774-129854970 (+)
A/J ENSMUSG00195008175
 protein coding gene Chr3:129897641-129965889 (+)
AKR/J ENSMUSG00220022195
 protein coding gene Chr3:128338039-128406280 (+)
BALB/cJ ENSMUSG00180003705
 protein coding gene Chr3:129826525-129894771 (+)
C3H/HeJ ENSMUSG00175013516
 protein coding gene Chr3:129400245-129468484 (+)
C57BL/6NJ ENSMUSG00215018323
 protein coding gene Chr3:130171835-130240115 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025650
 protein coding gene Chr3:126726521-126800672 (+)
CAST/EiJ ENSTCUG00005003563
 protein coding gene Chr3:130500836-130572210 (+)
CBA/J ENSMUSG00210003871
 protein coding gene Chr3:130018026-130086267 (+)
DBA/2J ENSMUSG00185025929
 protein coding gene Chr3:130630663-130698851 (+)
FVB/NJ ENSMUSG00205022808
 protein coding gene Chr3:128957012-129025263 (+)
JF1/MsJ ENSUMUG00000015557
 protein coding gene Chr3:129386941-129459182 (+)
LP/J ENSMUSG00230002809
 protein coding gene Chr3:132605199-132673384 (+)
NOD/ShiLtJ ENSMUSG00190001209
 protein coding gene Chr3:131014655-131082931 (+)
NZO/HlLtJ ENSMUSG00225004777
 protein coding gene Chr3:135050938-135120204 (+)
PWK/PhJ ENSLUMG00010014582
 protein coding gene Chr3:129367068-129432486 (+)
SPRET/EiJ ENSMSPG00010012449
 protein coding gene Chr3:130409432-130488564 (+)
WSB/EiJ ENSIUOG00005016566
 protein coding gene Chr3:130153963-130222907 (+)



Homology
more
  • Human Ortholog
    PPA2, inorganic pyrophosphatase 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PPA2, inorganic pyrophosphatase 2
  • Synonyms
    HSPC124, SCFAI, SCFI, SID6-306
  • Links
    NCBI Gene ID: 27068
    UniProt: Q9H2U2

  • Chr Location
    4q24; chr4:105369077-105474113 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    2
  • Gene trapped
    4
  • Radiation induced
    1
  • Genomic Mutations
    2 involving Ppa2
  • Incidental Mutations
    Mutagenetix , APF , CvDC
  • Find Mice (IMSR)
    26 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    691
  • Tissues
    94
  • cDNA Data
    69
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000028013 Ensembl Gene Model | MGI Sequence Detail 68126 C57BL/6J ±  kb
transcript ENSMUST00000029644 Ensembl | MGI Sequence Detail 1226 Not Applicable  
polypeptide ENSMUSP00000029644 Ensembl | MGI Sequence Detail 330 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 69
    cDNA 69

    Microarray probesets 3
References
more
  • Summaries
    All 46
    Developmental Gene Expression 1
    Diseases 1
    Gene Ontology 13
    Phenotypes 13
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory