About   Help   FAQ
Ptchd3 Gene Detail
Summary
  • Symbol
    Ptchd3
  • Name
    patched domain containing 3
  • Synonyms
    4930451E13Rik, 4933440L20Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921925
    NCBI Gene: 74675
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:121721073-121734249 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 87.90 cM, cytoband E2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    280 from dbSNP Build 142
  • Strain Annotations
    16
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921925
 protein coding gene Chr11:121721050-121734259 (+)
129S1/SvImJ no annotation
A/J ENSMUSG00195029409
 protein coding gene Chr11:118760888-118787662 (+)
AKR/J ENSMUSG00220023603
 protein coding gene Chr11:118911233-118938005 (+)
BALB/cJ ENSMUSG00180048428
 protein coding gene Chr11:119057702-119084480 (+)
C3H/HeJ ENSMUSG00175036718
 protein coding gene Chr11:119011253-119038023 (+)
C57BL/6NJ ENSMUSG00215042017
 protein coding gene Chr11:118581339-118608110 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017570
 protein coding gene Chr11:117726185-117739672 (+)
CAST/EiJ ENSTCUG00005027001
 protein coding gene Chr11:118424549-118446208 (+)
CBA/J ENSMUSG00210049476
 protein coding gene Chr11:118725295-118752066 (+)
DBA/2J ENSMUSG00185020840
 protein coding gene Chr11:119038442-119065212 (+)
FVB/NJ no annotation
JF1/MsJ no annotation
LP/J ENSMUSG00230047925
 protein coding gene Chr11:120099944-120126711 (+)
NOD/ShiLtJ ENSMUSG00190029205
 protein coding gene Chr11:119109666-119136435 (+)
NZO/HlLtJ ENSMUSG00225026693
 protein coding gene Chr11:122269927-122296704 (+)
PWK/PhJ ENSLUMG00010020588
 protein coding gene Chr11:118825247-118848151 (+)
SPRET/EiJ ENSMSPG00010041691
 protein coding gene Chr11:119468424-119488350 (+)
WSB/EiJ ENSIUOG00005040853
 protein coding gene Chr11:118848721-118861897 (+)



Homology
more
  • Human Ortholog
    PTCHD3, patched domain containing 3 (gene/pseudogene)
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PTCHD3, patched domain containing 3 (gene/pseudogene)
  • Synonyms
    PTR, SLC65C3
  • Links
    NCBI Gene ID: 374308
    UniProt: Q3KNS1

  • Chr Location
    10p12.1; chr10:27397121-27414368 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are viable and live normally into adulthood with no apparent defects in male fertility or spermatogenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000039198 Ensembl Gene Model | MGI Sequence Detail 13177 C57BL/6J ±  kb
    transcript ENSMUST00000036690 Ensembl | MGI Sequence Detail 3194 Not Applicable  
    polypeptide ENSMUSP00000035709 Ensembl | MGI Sequence Detail 906 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 5
      cDNA 5

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:1914032
    References
    more
    • Summaries
      All 37
      Gene Ontology 9
      Phenotypes 10
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory