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Prss46 Gene Detail
Summary
  • Symbol
    Prss46
  • Name
    serine protease 46
  • Synonyms
    1700112C13Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921556
    NCBI Gene: 74306
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:110673574-110685586 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 60.79 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    399 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921556
 protein coding gene Chr9:110673574-110685590 (+)
129S1/SvImJ ENSMUSG00200039930
 protein coding gene Chr9:107766933-107778964 (+)
A/J ENSMUSG00195033693
 protein coding gene Chr9:107060462-107072503 (+)
AKR/J ENSMUSG00220027885
 protein coding gene Chr9:107396098-107408145 (+)
BALB/cJ ENSMUSG00180029314
 protein coding gene Chr9:107515347-107527384 (+)
C3H/HeJ ENSMUSG00175031569
 protein coding gene Chr9:107731161-107743187 (+)
C57BL/6NJ ENSMUSG00215019596
 protein coding gene Chr9:107611297-107623315 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032744
 protein coding gene Chr9:106127262-106139530 (+)
CAST/EiJ ENSTCUG00005034067
 protein coding gene Chr9:107424090-107434899 (+)
CBA/J ENSMUSG00210027016
 protein coding gene Chr9:107458074-107469011 (+)
DBA/2J ENSMUSG00185033104
 protein coding gene Chr9:107779103-107791132 (+)
FVB/NJ ENSMUSG00205022602
 protein coding gene Chr9:107726818-107738854 (+)
JF1/MsJ ENSUMUG00000022323
 protein coding gene Chr9:107558941-107569916 (+)
LP/J ENSMUSG00230042860
 protein coding gene Chr9:107899038-107911075 (+)
NOD/ShiLtJ ENSMUSG00190048883
 protein coding gene Chr9:107366771-107378801 (+)
NZO/HlLtJ ENSMUSG00225023002
 protein coding gene Chr9:108157516-108169550 (+)
PWK/PhJ ENSLUMG00010035726
 protein coding gene Chr9:107566640-107577517 (+)
SPRET/EiJ ENSMSPG00010034235
 protein coding gene Chr9:109351733-109363921 (+)
WSB/EiJ ENSIUOG00005037559
 protein coding gene Chr9:106820613-106832622 (+)



Homology
more
  • Human Ortholog
    PRSS46P, serine protease 46, pseudogene
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PRSS46P, serine protease 46, pseudogene
  • Synonyms
    PRSS46, TESSP6
  • Links
    NCBI Gene ID: 100287362
    UniProt: E5RG02

  • Chr Location
    chr3:46719583-46736429 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from multigenic genotypes
    14 phenotype references
Male mice homozygous for a null allele exhibit normal fertility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    6
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    5
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 74306 NCBI Gene Model | MGI Sequence Detail 12013 C57BL/6J ±  kb
transcript NM_183103 RefSeq | MGI Sequence Detail 1253 C57BL/6  
polypeptide Q5M8S2 UniProt | EBI | MGI Sequence Detail 314 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 5
    cDNA 5

    Microarray probesets 2
References
more
  • Summaries
    All 32
    Gene Ontology 3
    Phenotypes 14
  • Earliest
    J:13132 DEOL MS, et al., The spinner mouse. J Hered. 1962 May-Jun;53:133-6
  • Latest
    J:386576 George SS, et al., Auditory Hair Cell Mechanotransduction Channels Dynamically Shape the Mechanical Properties of Their Membrane Environment. Adv Sci (Weinh). 2026 Feb;13(7):e08268
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/15/2026
MGI 6.29 		The Jackson Laboratory