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Chic2 Gene Detail
Summary
  • Symbol
    Chic2
  • Name
    cysteine-rich hydrophobic domain 2
  • Synonyms
    1700081B18Rik, 4930502K01Rik, BTL
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921527
    NCBI Gene: 74277
  • Alliance
    genome feature page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:75165665-75205302 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 39.54 cM, cytoband D
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    714 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921527
 protein coding gene Chr5:75158649-75205435 (-)
129S1/SvImJ ENSMUSG00200000827
 protein coding gene Chr5:70838809-70885631 (-)
A/J ENSMUSG00195030446
 protein coding gene Chr5:70150153-70196954 (-)
AKR/J ENSMUSG00220002998
 protein coding gene Chr5:70255059-70301892 (-)
BALB/cJ ENSMUSG00180021068
 protein coding gene Chr5:69900381-69947217 (-)
C3H/HeJ ENSMUSG00175004201
 protein coding gene Chr5:71964033-72010855 (-)
C57BL/6NJ ENSMUSG00215000443
 protein coding gene Chr5:70734729-70781513 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027306
 protein coding gene Chr5:67927049-67975407 (-)
CAST/EiJ ENSTCUG00005028452
 protein coding gene Chr5:69711652-69758669 (-)
CBA/J ENSMUSG00210000409
 protein coding gene Chr5:70902065-70948896 (-)
DBA/2J ENSMUSG00185016447
 protein coding gene Chr5:72732006-72778824 (-)
FVB/NJ ENSMUSG00205022025
 protein coding gene Chr5:69673239-69720047 (-)
JF1/MsJ ENSUMUG00000004378
 protein coding gene Chr5:77231031-77278031 (-)
LP/J ENSMUSG00230015695
 protein coding gene Chr5:77412956-77459768 (-)
NOD/ShiLtJ ENSMUSG00190004137
 protein coding gene Chr5:69848779-69895606 (-)
NZO/HlLtJ ENSMUSG00225033312
 protein coding gene Chr5:82469518-82516304 (-)
PWK/PhJ ENSLUMG00010012885
 protein coding gene Chr5:69806307-69854027 (-)
SPRET/EiJ ENSMSPG00010009093
 protein coding gene Chr5:71795136-71841777 (-)
WSB/EiJ ENSIUOG00005017393
 protein coding gene Chr5:72669229-72716092 (-)



Homology
more
  • Human Ortholog
    CHIC2, cysteine rich hydrophobic domain 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CHIC2, cysteine rich hydrophobic domain 2
  • Synonyms
    BTL
  • Links
    NCBI Gene ID: 26511
    UniProt: Q9UKJ5

  • Chr Location
    4q12; chr4:53994803-54091879 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human CHIC2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    410 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    654
  • Tissues
    41
  • cDNA Data
    78
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 74277 NCBI Gene Model | MGI Sequence Detail 39638 C57BL/6J ±  kb
    transcript NM_028850 RefSeq | MGI Sequence Detail 2550 C57BL/6  
    polypeptide Q9D9G3 UniProt | EBI | MGI Sequence Detail 165 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000031951 cysteine-rich hydrophobic domain-containing protein 2
      (term hierarchy)
    • InterPro Domains
      IPR039735 Cysteine-rich hydrophobic domain-containing protein 1/2
      IPR019383 Golgin subfamily A member 7/ERF4
    Molecular
    Reagents
    less
    • All nucleic 78
      cDNA 78

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1922202
    References
    more
    • Summaries
      All 438
      Developmental Gene Expression 1
      Diseases 1
      Gene Ontology 5
      Phenotypes 410
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:392487 Choi MY, et al., Peritoneal mast cell-derived IL-10 promotes peritoneal-colon tolerance by reprogramming macrophages to ameliorate colitis. Sci Rep. 2026 Jul 15;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory