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Prss51 Gene Detail
Summary
  • Symbol
    Prss51
  • Name
    serine protease 51
  • Synonyms
    1700007N14Rik
Location &
Maps
more
  • Sequence Map
    Chr14:64323683-64335127 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 33.35 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    402 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921465
 protein coding gene Chr14:64322974-64335127 (+)
129S1/SvImJ ENSMUSG00200025951
 protein coding gene Chr14:52950508-52961874 (+)
A/J ENSMUSG00195013148
 protein coding gene Chr14:53122561-53134005 (+)
AKR/J ENSMUSG00220027219
 protein coding gene Chr14:52463074-52474516 (+)
BALB/cJ ENSMUSG00180032811
 protein coding gene Chr14:52738684-52750122 (+)
C3H/HeJ ENSMUSG00175036074
 protein coding gene Chr14:54486885-54498255 (+)
C57BL/6NJ ENSMUSG00215017085
 protein coding gene Chr14:52656317-52667759 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019414
 protein coding gene Chr14:55235936-55246787 (+)
CAST/EiJ ENSTCUG00005036398
 protein coding gene Chr14:54382205-54393690 (+)
CBA/J ENSMUSG00210038769
 protein coding gene Chr14:53110021-53121463 (+)
DBA/2J ENSMUSG00185030689
 protein coding gene Chr14:58284719-58296085 (+)
FVB/NJ ENSMUSG00205026364
 protein coding gene Chr14:52625401-52636844 (+)
JF1/MsJ ENSUMUG00000044691
 protein coding gene Chr14:69450502-69461857 (+)
LP/J ENSMUSG00230033795
 protein coding gene Chr14:70314117-70325475 (+)
NOD/ShiLtJ ENSMUSG00190035540
 protein coding gene Chr14:52904749-52916202 (+)
NZO/HlLtJ ENSMUSG00225045158
 protein coding gene Chr14:60637739-60649180 (+)
PWK/PhJ ENSLUMG00010033991
 protein coding gene Chr14:52335501-52346813 (+)
SPRET/EiJ ENSMSPG00010027039
 protein coding gene Chr14:55814854-55826204 (+)
WSB/EiJ ENSIUOG00005039210
 protein coding gene Chr14:52341871-52353308 (+)



Homology
more
  • Human Ortholog
    PRSS51, serine protease 51
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PRSS51, serine protease 51
  • Links
    NCBI Gene ID: 346702
    UniProt: A0A1B0GVH4

  • Chr Location
    8p23.1; chr8:10481293-10547723 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from multigenic genotypes
    6 phenotype references
Mice homozygous for a null allele exhibit normal male fertility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    4
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000052099 Ensembl Gene Model | MGI Sequence Detail 11445 C57BL/6J ±  kb
transcript ENSMUST00000224112 Ensembl | MGI Sequence Detail 1042 Not Applicable  
polypeptide ENSMUSP00000153617 Ensembl | MGI Sequence Detail 319 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    5 Sequences
  • EC
    3.4.21.1
  • InterPro Domains
    IPR001314 Peptidase S1A, chymotrypsin family
    IPR009003 Peptidase S1, PA clan
    IPR018114 Serine protease-like, trypsin family, histidine active site
    IPR001254 Serine proteases, trypsin domain
Molecular
Reagents
less
  • All nucleic 4
    cDNA 4

    Microarray probesets 3
References
more
  • Summaries
    All 27
    Gene Ontology 4
    Phenotypes 6
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:293896 Kobayashi K, et al., Prss55 but not Prss51 is required for male fertility in mice. Biol Reprod. 2020 Aug 4;103(2):223-234
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/15/2026
MGI 6.29 		The Jackson Laboratory