Scyl3 MGI Mouse Gene Detail - MGI:1921385 - SCY1-like 3 (S. cerevisiae)

Symbol

Scyl3
Name

SCY1-like 3 (S. cerevisiae)
Synonyms

1200016D23Rik, Pace1

Feature Type

protein coding gene
IDs

MGI:1921385
NCBI Gene: 240880
Alliance

genome feature page
Transcription Start Sites

2 TSS

Sequence Map

Chr1:163756669-163782695 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 71.23 cM
Mapping Data

2 experiments

SNPs within 2kb

648 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1921385	protein coding gene	Chr1:163756669-163782695 (+)
129S1/SvImJ	ENSMUSG00200006445	protein coding gene	Chr1:161231382-161253027 (+)
A/J	ENSMUSG00195019541	protein coding gene	Chr1:160571617-160593264 (+)
AKR/J	ENSMUSG00220013768	protein coding gene	Chr1:160350259-160371965 (+)
BALB/cJ	ENSMUSG00180035388	protein coding gene	Chr1:160812834-160835179 (+)
C3H/HeJ	ENSMUSG00175041867	protein coding gene	Chr1:160904211-160925858 (+)
C57BL/6NJ	ENSMUSG00215036861	protein coding gene	Chr1:160781404-160803047 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014786	protein coding gene	Chr1:154410308-154435440 (+)
CAST/EiJ	ENSTCUG00005019178	protein coding gene	Chr1:159368158-159390199 (+)
CBA/J	ENSMUSG00210020921	protein coding gene	Chr1:160776822-160798467 (+)
DBA/2J	ENSMUSG00185011418	protein coding gene	Chr1:165022123-165043911 (+)
FVB/NJ	ENSMUSG00205008644	protein coding gene	Chr1:159855412-159877077 (+)
JF1/MsJ	ENSUMUG00000005252	protein coding gene	Chr1:164172406-164194132 (+)
LP/J	ENSMUSG00230021778	protein coding gene	Chr1:164641813-164663460 (+)
NOD/ShiLtJ	ENSMUSG00190037091	protein coding gene	Chr1:160617936-160639601 (+)
NZO/HlLtJ	ENSMUSG00225003472	protein coding gene	Chr1:168235093-168256758 (+)
PWK/PhJ	ENSLUMG00010040180	protein coding gene	Chr1:159561932-159583837 (+)
SPRET/EiJ	ENSMSPG00010040157	protein coding gene	Chr1:163041030-163067130 (+)
WSB/EiJ	ENSIUOG00005013785	protein coding gene	Chr1:160121561-160143223 (+)

Human Ortholog

SCYL3, SCY1 like pseudokinase 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SCYL3, SCY1 like pseudokinase 3
Synonyms

PACE-1, PACE1
Links

HGNC:19285

NCBI Gene ID: 57147

UniProt: Q8IZE3
Chr Location

1q24.2; chr1:169846981-169894268 (-) GRCh38

MGI Vertebrate Homology

Scyl3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SCYL3
Gene Tree

Scyl3

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
14 phenotypes from multigenic genotypes
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

16
Chemically induced (other)

2
Endonuclease-mediated

1
Gene trapped

9
Targeted

4
Genomic Mutations

2 involving Scyl3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

31 strains or lines available

Mice exhibit angulated muscle fibers but normal T- and B-cell development and homeostasis.

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All GO Annotations

23
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

606
Tissues

5
cDNA Data

72
Literature Summary

2

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase scyl3

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All Sequences

79
RefSeq

28
UniProt

3
CCDS

CCDS15430.1, CCDS69967.1

Ensembl

ENSMUSG00000026584 (Evidence)
NCBI Gene

240880

			Length	Strain/Species	Flank
genomic	240880	NCBI Gene Model \| MGI Sequence Detail	26027	C57BL/6J	± kb
transcript	NM_001357426	RefSeq \| MGI Sequence Detail	4454	C57BL/6
polypeptide	Q9DBQ7	UniProt \| EBI \| MGI Sequence Detail	735	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000014550 protein-associating with the carboxyl-terminal domain of ezrin

(term hierarchy)
InterPro Domains

IPR011989 Armadillo-like helical

IPR016024 Armadillo-type fold

IPR051177 Catalytically Inactive Kinase-Related Protein

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

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All nucleic 73

cDNA 73

Microarray probesets 6

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MGI:2138578

Summaries

All 38

Developmental Gene Expression 2

Gene Ontology 5

Phenotypes 11
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Scyl3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr9739	Chr1:163757347-163757378 (+)	694 bp
Tssr9740	Chr1:163757574-163757646 (+)	941 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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