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Ddias Gene Detail
Summary
  • Symbol
    Ddias
  • Name
    DNA damage-induced apoptosis suppressor
  • Synonyms
    4632434I11Rik, noxin
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921291
    NCBI Gene: 74041
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:92506734-92523455 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 51.64 cM, cytoband E2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    581 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921291
 protein coding gene Chr7:92506733-92523455 (-)
129S1/SvImJ ENSMUSG00200026819
 protein coding gene Chr7:79288222-79306351 (-)
A/J ENSMUSG00195037202
 protein coding gene Chr7:83796249-83812973 (-)
AKR/J ENSMUSG00220040708
 protein coding gene Chr7:77262276-77279000 (-)
BALB/cJ ENSMUSG00180036248
 protein coding gene Chr7:80464564-80481288 (-)
C3H/HeJ ENSMUSG00175022116
 protein coding gene Chr7:81173360-81191501 (-)
C57BL/6NJ ENSMUSG00215027064
 protein coding gene Chr7:80346923-80363643 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029993
 protein coding gene Chr7:95817108-95834899 (-)
CAST/EiJ ENSTCUG00005031260
 protein coding gene Chr7:83748985-83766829 (-)
CBA/J ENSMUSG00210025022
 protein coding gene Chr7:81015203-81033344 (-)
DBA/2J ENSMUSG00185030136
 protein coding gene Chr7:85344975-85363114 (-)
FVB/NJ ENSMUSG00205015660
 protein coding gene Chr7:80974101-80992237 (-)
JF1/MsJ ENSUMUG00000015097
 protein coding gene Chr7:90286845-90304619 (-)
LP/J ENSMUSG00230041493
 protein coding gene Chr7:91433998-91452137 (-)
NOD/ShiLtJ ENSMUSG00190018512
 protein coding gene Chr7:81215709-81232431 (-)
NZO/HlLtJ ENSMUSG00225010103
 protein coding gene Chr7:89709047-89727186 (-)
PWK/PhJ no annotation
SPRET/EiJ ENSMSPG00010011847
 protein coding gene Chr7:80611913-80629741 (-)
WSB/EiJ ENSIUOG00005008987
 protein coding gene Chr7:81650134-81668409 (-)



Homology
more
  • Human Ortholog
    DDIAS, DNA damage induced apoptosis suppressor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DDIAS, DNA damage induced apoptosis suppressor
  • Synonyms
    C11orf82, noxin
  • Links
    NCBI Gene ID: 220042
    UniProt: Q8IXT1

  • Chr Location
    11q14.1; chr11:82899975-82958277 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 2 alleles in 2 genetic backgrounds
    35 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele show an enlarged heart, several altered hematopoietic parameters, decreased number of spermatids, and increased cell death and increased cell sensitivity to induced-stress.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    6
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 74041 NCBI Gene Model | MGI Sequence Detail 16722 C57BL/6J ±  kb
    transcript NM_001368705 RefSeq | MGI Sequence Detail 3473 C57BL/6  
    polypeptide Q6NZG4 UniProt | EBI | MGI Sequence Detail 898 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 6
      cDNA 6

      Microarray probesets 3
    References
    more
    • Summaries
      All 58
      Gene Ontology 6
      Phenotypes 35
    • Earliest
      J:141526 Russell LB, et al., Analysis of the albino-locus region of the mouse. III. Time of death of prenatal lethals. Genetics. 1979 May;92(1):205-13
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory