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Ift54 Gene Detail
Summary
  • Symbol
    Ift54
  • Name
    intraflagellar transport 54
  • Synonyms
    3930402D05Rik, MIP-T3, Traf3ip1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921269
    NCBI Gene: 74019
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:91422369-91457029 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 46.16 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    925 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921269
 protein coding gene Chr1:91422311-91457029 (+)
129S1/SvImJ ENSMUSG00200036802
 protein coding gene Chr1:88641710-88676310 (+)
A/J ENSMUSG00195026310
 protein coding gene Chr1:88200279-88235001 (+)
AKR/J ENSMUSG00220041438
 protein coding gene Chr1:88350834-88385440 (+)
BALB/cJ ENSMUSG00180015944
 protein coding gene Chr1:88514581-88549319 (+)
C3H/HeJ ENSMUSG00175001335
 protein coding gene Chr1:88386122-88420841 (+)
C57BL/6NJ ENSMUSG00215027749
 protein coding gene Chr1:88322904-88357616 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014425
 protein coding gene Chr1:83941123-83975769 (+)
CAST/EiJ ENSTCUG00005007159
 protein coding gene Chr1:87947973-87983206 (+)
CBA/J ENSMUSG00210011556
 protein coding gene Chr1:88231404-88266128 (+)
DBA/2J ENSMUSG00185013929
 protein coding gene Chr1:92701144-92735886 (+)
FVB/NJ ENSMUSG00205032196
 protein coding gene Chr1:87639096-87673690 (+)
JF1/MsJ ENSUMUG00000015474
 protein coding gene Chr1:91439494-91474688 (+)
LP/J ENSMUSG00230021663
 protein coding gene Chr1:91977860-92012457 (+)
NOD/ShiLtJ ENSMUSG00190025089
 protein coding gene Chr1:88282320-88317062 (+)
NZO/HlLtJ ENSMUSG00225001810
 protein coding gene Chr1:95879262-95913841 (+)
PWK/PhJ ENSLUMG00010043026
 protein coding gene Chr1:87831103-87866190 (+)
SPRET/EiJ ENSMSPG00010042831
 protein coding gene Chr1:89863475-89898254 (+)
WSB/EiJ ENSIUOG00005035454
 protein coding gene Chr1:87945268-87980078 (+)



Homology
more
  • Human Ortholog
    IFT54, intraflagellar transport 54
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IFT54, intraflagellar transport 54
  • Synonyms
    CFAP116, FAP116, MIP-T3, MIPT3, SLSN9, TRAF3IP1
  • Links
    NCBI Gene ID: 26146
    UniProt: Q8TDR0

  • Chr Location
    2q37.3; chr2:238320441-238402114 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human IFT54 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele exhibit embryonic lethality, cardiac edema, abnormal neural development, polydactyly, and microphthalmia associated with a lack of embryonic lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    75
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    632
  • Tissues
    17
  • cDNA Data
    11
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000034292 Ensembl Gene Model | MGI Sequence Detail 34661 C57BL/6J ±  kb
    transcript ENSMUST00000189341 Ensembl | MGI Sequence Detail 2257 Not Applicable  
    polypeptide ENSMUSP00000140151 Ensembl | MGI Sequence Detail 654 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 11

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2138493, MGI:8348362
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 2
      Gene Ontology 16
      Phenotypes 14
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory