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Ppp1r42 Gene Detail
Summary
  • Symbol
    Ppp1r42
  • Name
    protein phosphatase 1, regulatory subunit 42
  • Synonyms
    1700011J18Rik, 4930418G15Rik, Lrrc67
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921138
    NCBI Gene: 69312
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:10038849-10079361 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 2.25 cM, cytoband A2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1277 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921138
 protein coding gene Chr1:10038847-10083766 (-)
129S1/SvImJ ENSMUSG00200002291
 protein coding gene Chr1:7363222-7398048 (-)
A/J ENSMUSG00195002786
 protein coding gene Chr1:7180962-7215791 (-)
AKR/J ENSMUSG00220003213
 protein coding gene Chr1:7281340-7316170 (-)
BALB/cJ ENSMUSG00180008561
 protein coding gene Chr1:7264527-7299347 (-)
C3H/HeJ ENSMUSG00175000109
 protein coding gene Chr1:7160569-7195430 (-)
C57BL/6NJ ENSMUSG00215003968
 protein coding gene Chr1:7223255-7258095 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0013944
 protein coding gene Chr1:6126587-6167140 (-)
CAST/EiJ ENSTCUG00005001932
 protein coding gene Chr1:7603641-7636061 (-)
CBA/J ENSMUSG00210001598
 protein coding gene Chr1:7020062-7054925 (-)
DBA/2J ENSMUSG00185004319
 protein coding gene Chr1:8108763-8143743 (-)
FVB/NJ ENSMUSG00205004666
 protein coding gene Chr1:7358341-7393167 (-)
JF1/MsJ ENSUMUG00000002057
 protein coding gene Chr1:7390958-7426822 (-)
LP/J ENSMUSG00230002113
 protein coding gene Chr1:8104916-8139744 (-)
NOD/ShiLtJ ENSMUSG00190001195
 protein coding gene Chr1:7172645-7207617 (-)
NZO/HlLtJ ENSMUSG00225004775
 protein coding gene Chr1:11506901-11541731 (-)
PWK/PhJ ENSLUMG00010002257
 protein coding gene Chr1:6995689-7031400 (-)
SPRET/EiJ ENSMSPG00010013729
 protein coding gene Chr1:7600369-7637775 (-)
WSB/EiJ ENSIUOG00005010704
 protein coding gene Chr1:7187566-7222543 (-)



Homology
more
  • Human Ortholog
    PPP1R42, protein phosphatase 1 regulatory subunit 42
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PPP1R42, protein phosphatase 1 regulatory subunit 42
  • Synonyms
    dtr, LRRC67, TLLR, TLRR
  • Links
    NCBI Gene ID: 286187
    UniProt: Q7Z4L9

  • Chr Location
    8q13.1; chr8:66964099-67056604 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Male mice homozygous for a null allele exhibit normal fertility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    630
  • Tissues
    2
  • cDNA Data
    5
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025916 Ensembl Gene Model | MGI Sequence Detail 40513 C57BL/6J ±  kb
    transcript ENSMUST00000027049 Ensembl | MGI Sequence Detail 1425 Not Applicable  
    polypeptide ENSMUSP00000027049 Ensembl | MGI Sequence Detail 357 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 5
      cDNA 5

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1916562
    References
    more
    • Summaries
      All 31
      Developmental Gene Expression 1
      Gene Ontology 5
      Phenotypes 7
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:348447 Nguyen TTT, et al., Gene-deficient mouse model established by CRISPR/Cas9 system reveals 15 reproductive organ-enriched genes dispensable for male fertility. Frontiers in Cell and Developmental Biology. 2024;12
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory