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Ppp1r21 Gene Detail
Summary
  • Symbol
    Ppp1r21
  • Name
    protein phosphatase 1, regulatory subunit 21
  • Synonyms
    1110018J12Rik, Ccdc128, Klraq1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921075
    NCBI Gene: 73825
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:88837552-88895795 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 58.02 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2396 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921075
 protein coding gene Chr17:88837546-88895795 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024110
 protein coding gene Chr17:92024067-92084749 (+)
A/J MGP_AJ_G0024070
 protein coding gene Chr17:89051329-89112691 (+)
AKR/J MGP_AKRJ_G0024039
 protein coding gene Chr17:90545048-90602650 (+)
BALB/cJ MGP_BALBcJ_G0024071
 protein coding gene Chr17:88880559-88938624 (+)
C3H/HeJ MGP_C3HHeJ_G0023836
 protein coding gene Chr17:91438489-91496406 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024516
 protein coding gene Chr17:95225257-95288647 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021954
 protein coding gene Chr17:84111679-84171443 (+)
CAST/EiJ MGP_CASTEiJ_G0023315
 protein coding gene Chr17:92303572-92364421 (+)
CBA/J MGP_CBAJ_G0023809
 protein coding gene Chr17:99249489-99311074 (+)
DBA/2J MGP_DBA2J_G0023938
 protein coding gene Chr17:87438584-87496356 (+)
FVB/NJ MGP_FVBNJ_G0023904
 protein coding gene Chr17:86972242-87029589 (+)
LP/J MGP_LPJ_G0024022
 protein coding gene Chr17:92820539-92881046 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023932
 protein coding gene Chr17:99037049-99097304 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024561
 protein coding gene Chr17:91088036-91150347 (+)
PWK/PhJ MGP_PWKPhJ_G0023060
 protein coding gene Chr17:87135196-87196468 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022871
 protein coding gene Chr17:87826548-87888617 (+)
WSB/EiJ MGP_WSBEiJ_G0023381
 protein coding gene Chr17:91944463-92008389 (+)



Homology
more
  • Human Ortholog
    PPP1R21, protein phosphatase 1 regulatory subunit 21
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PPP1R21, protein phosphatase 1 regulatory subunit 21
  • Synonyms
    CCDC128, FERRY2, Fy-2, KLRAQ1, NEDHFBA
  • Links
    NCBI Gene ID: 129285
    UniProt: Q6ZMI0

  • Chr Location
    2p16.3; chr2:48440598-48515391 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    791
  • Tissues
    12
  • cDNA Data
    10
  • Literature Summary
    2
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 73825 NCBI Gene Model | MGI Sequence Detail 58244 C57BL/6J ±  kb
transcript NM_028658 RefSeq | MGI Sequence Detail 3151 C57BL/6  
polypeptide Q3TDD9 UniProt | EBI | MGI Sequence Detail 780 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000029691 protein phosphatase 1 regulatory subunit 21
    (term hierarchy)
  • InterPro Domains
    IPR040024 Protein phosphatase 1 regulatory subunit 21
    IPR049372 Protein phosphatase 1 regulatory subunit 21, C-terminal
    IPR019343 Protein phosphatase 1 regulatory subunit 21, N-terminal
    IPR019348 Protein phosphatase 1 regulatory subunit 21, six-helix bundle
  • GlyGen
    Q3TDD9 1 site, 1 N-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 10
    cDNA 10

    Microarray probesets 3
Other
Accession IDs
less
MGI:2146849, MGI:2147082
References
more
  • Summaries
    All 36
    Developmental Gene Expression 2
    Gene Ontology 6
    Phenotypes 9
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory