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Kprp Gene Detail
Summary
  • Symbol
    Kprp
  • Name
    keratinocyte expressed, proline-rich
  • Synonyms
    1110001M24Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920981
    NCBI Gene: 433619
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:92730381-92734554 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 40.14 cM, cytoband F2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    157 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1920981
 protein coding gene Chr3:92730381-92734554 (-)
129S1/SvImJ ENSMUSG00200036947
 protein coding gene Chr3:89518006-89522221 (-)
A/J ENSMUSG00195052815
 protein coding gene Chr3:89527320-89531535 (-)
AKR/J ENSMUSG00220047525
 protein coding gene Chr3:88748540-88752713 (-)
BALB/cJ ENSMUSG00180040150
 protein coding gene Chr3:89698312-89702527 (-)
C3H/HeJ ENSMUSG00175040229
 protein coding gene Chr3:89465132-89469347 (-)
C57BL/6NJ ENSMUSG00215048494
 protein coding gene Chr3:90076884-90081057 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025285
 protein coding gene Chr3:86974545-86978757 (-)
CAST/EiJ ENSTCUG00005042374
 protein coding gene Chr3:89850644-89854864 (-)
CBA/J ENSMUSG00210040634
 protein coding gene Chr3:89580258-89584473 (-)
DBA/2J ENSMUSG00185050228
 protein coding gene Chr3:89782626-89786799 (-)
FVB/NJ ENSMUSG00205027069
 protein coding gene Chr3:88574553-88578726 (-)
JF1/MsJ ENSUMUG00000040168
 protein coding gene Chr3:89343260-89347473 (-)
LP/J ENSMUSG00230039041
 protein coding gene Chr3:91815476-91819691 (-)
NOD/ShiLtJ ENSMUSG00190047012
 protein coding gene Chr3:89901372-89905586 (-)
NZO/HlLtJ ENSMUSG00225009772
 protein coding gene Chr3:94663175-94667390 (-)
PWK/PhJ ENSLUMG00010046149
 protein coding gene Chr3:89401491-89405704 (-)
SPRET/EiJ ENSMSPG00010049350
 protein coding gene Chr3:89860295-89864540 (-)
WSB/EiJ ENSIUOG00005043317
 protein coding gene Chr3:90053169-90057383 (-)



Homology
more
  • Human Ortholog
    KPRP, keratinocyte proline rich protein
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KPRP, keratinocyte proline rich protein
  • Synonyms
    C1orf45
  • Links
    NCBI Gene ID: 448834
    UniProt: Q5T749

  • Chr Location
    1q21.3; chr1:152758025-152762056 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice heterozygous for a null allele show a thin stratum granulosum, detachment of lower layers of the stratum corneum, abnormal desmosome structure and enhanced percutaneous immune responses to irritants and allergens. Homozygotes show a similar phenotype as heterozygotes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    3
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 433619 NCBI Gene Model | MGI Sequence Detail 4174 C57BL/6J ±  kb
    transcript NM_028629 RefSeq | MGI Sequence Detail 2738 C57BL/6  
    polypeptide B2RUR4 UniProt | EBI | MGI Sequence Detail 657 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 9

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2139600
    References
    more
    • Summaries
      All 36
      Diseases 1
      Gene Ontology 3
      Phenotypes 10
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:335034 Li Y, et al., DYRK1a mediates BAFF-induced noncanonical NF-kappaB activation to promote autoimmunity and B-cell leukemogenesis. Blood. 2021 Dec 9;138(23):2360-2371
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory