About   Help   FAQ
Glipr1 Gene Detail
Summary
  • Symbol
    Glipr1
  • Name
    GLI pathogenesis related 1
  • Synonyms
    2410114O14Rik, mRTVP-1, RTVP-1, RTVP1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920940
    NCBI Gene: 73690
  • Alliance
    genome feature page
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:111821353-111838536 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 59.98 cM, cytoband D1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    684 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1920940
 protein coding gene Chr10:111821353-111838539 (-)
129S1/SvImJ ENSMUSG00200009974
 protein coding gene Chr10:108240297-108257473 (-)
A/J ENSMUSG00195008170
 protein coding gene Chr10:108655806-108672966 (-)
AKR/J ENSMUSG00220024365
 protein coding gene Chr10:108237182-108254355 (-)
BALB/cJ ENSMUSG00180023352
 protein coding gene Chr10:108675274-108692440 (-)
C3H/HeJ ENSMUSG00175015093
 protein coding gene Chr10:108603624-108620795 (-)
C57BL/6NJ ENSMUSG00215008354
 protein coding gene Chr10:108326594-108343771 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015801
 protein coding gene Chr10:104938060-104955815 (-)
CAST/EiJ ENSTCUG00005011279
 protein coding gene Chr10:107700326-107717470 (-)
CBA/J ENSMUSG00210011218
 protein coding gene Chr10:108474932-108492102 (-)
DBA/2J ENSMUSG00185023753
 protein coding gene Chr10:108610053-108627213 (-)
FVB/NJ ENSMUSG00205010035
 protein coding gene Chr10:108103980-108121149 (-)
JF1/MsJ ENSUMUG00000007675
 protein coding gene Chr10:109932606-109951099 (-)
LP/J ENSMUSG00230011738
 protein coding gene Chr10:110549501-110566672 (-)
NOD/ShiLtJ ENSMUSG00190020122
 protein coding gene Chr10:108702671-108719840 (-)
NZO/HlLtJ ENSMUSG00225016137
 protein coding gene Chr10:114803845-114821020 (-)
PWK/PhJ ENSLUMG00010013898
 protein coding gene Chr10:108305857-108318566 (-)
SPRET/EiJ ENSMSPG00010005483
 protein coding gene Chr10:110152579-110164457 (-)
WSB/EiJ ENSIUOG00005010139
 protein coding gene Chr10:108376009-108393172 (-)



Homology
more
  • Human Ortholog
    GLIPR1, GLI pathogenesis related 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GLIPR1, GLI pathogenesis related 1
  • Synonyms
    CRISP7, GLIPR, RTVP1
  • Links
    NCBI Gene ID: 11010
    UniProt: P48060

  • Chr Location
    12q21.2; chr12:75480753-75503863 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Targeted inactivation of this gene renders mice more vulnerable to spontaneous tumorigenesis, leading to the formation of a wide spectrum of tumors and significantly shorter tumor-free survival times.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    4
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    598
  • Tissues
    1
  • cDNA Data
    30
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000056888 Ensembl Gene Model | MGI Sequence Detail 17184 C57BL/6J ±  kb
    transcript ENSMUST00000162508 Ensembl | MGI Sequence Detail 1183 Not Applicable  
    polypeptide ENSMUSP00000123990 Ensembl | MGI Sequence Detail 255 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 32
      cDNA 32

      Microarray probesets 2
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 1
      Gene Ontology 3
      Phenotypes 14
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory