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Capn9 Gene Detail
Summary
  • Symbol
    Capn9
  • Name
    calpain 9
  • Synonyms
    GC36, nCL-4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920897
    NCBI Gene: 73647
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:125302850-125345470 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 72.81 cM, cytoband E2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1422 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1920897
 protein coding gene Chr8:125301361-125345470 (+)
129S1/SvImJ ENSMUSG00200041518
 protein coding gene Chr8:119554804-119597514 (+)
A/J ENSMUSG00195024879
 protein coding gene Chr8:119840813-119878865 (+)
AKR/J ENSMUSG00220037481
 protein coding gene Chr8:120025579-120063037 (+)
BALB/cJ ENSMUSG00180026058
 protein coding gene Chr8:119885693-119923738 (+)
C3H/HeJ ENSMUSG00175028892
 protein coding gene Chr8:119945010-119982460 (+)
C57BL/6NJ ENSMUSG00215031042
 protein coding gene Chr8:119534641-119577322 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031707
 protein coding gene Chr8:115728451-115767030 (+)
CAST/EiJ ENSTCUG00005029522
 protein coding gene Chr8:119293747-119331599 (+)
CBA/J ENSMUSG00210031711
 protein coding gene Chr8:119860661-119903322 (+)
DBA/2J ENSMUSG00185035254
 protein coding gene Chr8:126179577-126222254 (+)
FVB/NJ ENSMUSG00205030647
 protein coding gene Chr8:118833137-118870824 (+)
JF1/MsJ ENSUMUG00000032434
 protein coding gene Chr8:128393185-128431259 (+)
LP/J ENSMUSG00230025581
 protein coding gene Chr8:129737481-129780191 (+)
NOD/ShiLtJ ENSMUSG00190018935
 protein coding gene Chr8:119980824-120018283 (+)
NZO/HlLtJ ENSMUSG00225019351
 protein coding gene Chr8:133102094-133140203 (+)
PWK/PhJ ENSLUMG00010037426
 protein coding gene Chr8:119682379-119720407 (+)
SPRET/EiJ ENSMSPG00010001760
 protein coding gene Chr8:121870891-121909268 (+)
WSB/EiJ ENSIUOG00005028621
 protein coding gene Chr8:120654175-120696746 (+)



Homology
more
  • Human Ortholog
    CAPN9, calpain 9
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CAPN9, calpain 9
  • Synonyms
    GC36, nCL-4
  • Links
    NCBI Gene ID: 10753
    UniProt: O14815

  • Chr Location
    1q42.2; chr1:230747348-230804397 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human CAPN9 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased sensitivity to ethanol-induced gastric mucosa injury.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    598
  • Tissues
    1
  • cDNA Data
    7
  • Literature Summary
    1
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031981 Ensembl Gene Model | MGI Sequence Detail 42621 C57BL/6J ±  kb
transcript ENSMUST00000093033 Ensembl | MGI Sequence Detail 2330 Not Applicable  
polypeptide ENSMUSP00000090717 Ensembl | MGI Sequence Detail 690 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 7
    cDNA 7

    Microarray probesets 3
References
more
  • Summaries
    All 35
    Developmental Gene Expression 1
    Gene Ontology 4
    Phenotypes 9
  • Earliest
    J:73503 Lee HJ, et al., Molecular cloning and characterization of a novel tissue-specific calpain predominantly expressed in the digestive tract. Biol Chem. 1998 Feb;379(2):175-83
  • Latest
    J:277692 Kim DH, et al., Calpain 9 as a therapeutic target in TGFbeta-induced mesenchymal transition and fibrosis. Sci Transl Med. 2019 Jul 17;11(501)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory