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Spata18 Gene Detail
Summary
  • Symbol
    Spata18
  • Name
    spermatogenesis associated 18
  • Synonyms
    1700067I02Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920722
    NCBI Gene: 73472
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:73808722-73836855 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 39.03 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    768 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1920722
 protein coding gene Chr5:73808722-73836927 (+)
129S1/SvImJ ENSMUSG00200035347
 protein coding gene Chr5:69468031-69496178 (+)
A/J ENSMUSG00195030281
 protein coding gene Chr5:68792608-68820771 (+)
AKR/J ENSMUSG00220003203
 protein coding gene Chr5:68898121-68926260 (+)
BALB/cJ ENSMUSG00180022814
 protein coding gene Chr5:68549638-68577801 (+)
C3H/HeJ ENSMUSG00175025082
 protein coding gene Chr5:70625344-70653525 (+)
C57BL/6NJ ENSMUSG00215004949
 protein coding gene Chr5:69383994-69412129 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027300
 protein coding gene Chr5:66581754-66609884 (+)
CAST/EiJ ENSTCUG00005028819
 protein coding gene Chr5:68369628-68397782 (+)
CBA/J ENSMUSG00210022916
 protein coding gene Chr5:69563421-69591601 (+)
DBA/2J ENSMUSG00185016457
 protein coding gene Chr5:71393232-71421422 (+)
FVB/NJ ENSMUSG00205021745
 protein coding gene Chr5:68316552-68344709 (+)
JF1/MsJ ENSUMUG00000004268
 protein coding gene Chr5:75877607-75905799 (+)
LP/J ENSMUSG00230021201
 protein coding gene Chr5:76042286-76070441 (+)
NOD/ShiLtJ ENSMUSG00190003926
 protein coding gene Chr5:68492059-68520198 (+)
NZO/HlLtJ ENSMUSG00225009305
 protein coding gene Chr5:81112774-81140933 (+)
PWK/PhJ ENSLUMG00010011518
 protein coding gene Chr5:68437308-68465548 (+)
SPRET/EiJ ENSMSPG00010030739
 protein coding gene Chr5:70432372-70458326 (+)
WSB/EiJ ENSIUOG00005017209
 protein coding gene Chr5:71324652-71352796 (+)



Homology
more
  • Human Ortholog
    SPATA18, spermatogenesis associated 18
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SPATA18, spermatogenesis associated 18
  • Synonyms
    Mieap, SPETEX1
  • Links
    NCBI Gene ID: 132671
    UniProt: Q8TC71

  • Chr Location
    4q12; chr4:52051304-52097302 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from multigenic genotypes
    401 phenotype references
Homo- or heterozygous KO in mice also carrying one copy of the ApcMin allele leads to increased intestinal adenoma and adenocarcinoma tumor incidence and size. This double mutation and homozygous KO of the gene alone results in lower internal mitochondrial cristae density in small intestinal mucosal epithelium.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    44
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    15
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000029155 Ensembl Gene Model | MGI Sequence Detail 28134 C57BL/6J ±  kb
transcript ENSMUST00000071077 Ensembl | MGI Sequence Detail 1978 Not Applicable  
polypeptide ENSMUSP00000064308 Ensembl | MGI Sequence Detail 537 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 15
    cDNA 15

    Microarray probesets 3
References
more
  • Summaries
    All 427
    Diseases 1
    Gene Ontology 7
    Phenotypes 401
  • Earliest
    J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
  • Latest
    J:390040 Dang L, et al., Activation of Intestinal Mast Cells Contributes to Gut Damage After Cardiac Arrest in Mice. Shock. 2026 Jan 1;65(1):85-92
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory