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Ciz1 Gene Detail
Summary
  • Symbol
    Ciz1
  • Name
    CDKN1A interacting zinc finger protein 1
  • Synonyms
    0610038H21Rik, 2900056O04Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920234
    NCBI Gene: 68379
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:32252724-32268311 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 22.09 cM, cytoband B
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    411 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1920234
 protein coding gene Chr2:32242339-32270982 (+)
129S1/SvImJ ENSMUSG00200052658
 protein coding gene Chr2:29226063-29242477 (+)
A/J ENSMUSG00195049477
 protein coding gene Chr2:29327443-29343863 (+)
AKR/J ENSMUSG00220053486
 protein coding gene Chr2:29445337-29461752 (+)
BALB/cJ ENSMUSG00180051680
 protein coding gene Chr2:29342092-29358507 (+)
C3H/HeJ ENSMUSG00175053398
 protein coding gene Chr2:29308517-29324937 (+)
C57BL/6NJ ENSMUSG00215045687
 protein coding gene Chr2:29374013-29390428 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023430
 protein coding gene Chr2:28233641-28251209 (+)
CAST/EiJ ENSTCUG00005053191
 protein coding gene Chr2:29054531-29070924 (+)
CBA/J ENSMUSG00210015912
 protein coding gene Chr2:29381074-29397491 (+)
DBA/2J ENSMUSG00185051942
 protein coding gene Chr2:29240710-29257129 (+)
FVB/NJ ENSMUSG00205048703
 protein coding gene Chr2:29087454-29103873 (+)
JF1/MsJ ENSUMUG00000030900
 protein coding gene Chr2:29132282-29148701 (+)
LP/J ENSMUSG00230041123
 protein coding gene Chr2:31161603-31178017 (+)
NOD/ShiLtJ ENSMUSG00190049183
 protein coding gene Chr2:29341865-29358284 (+)
NZO/HlLtJ ENSMUSG00225007733
 protein coding gene Chr2:38918844-38935245 (+)
PWK/PhJ ENSLUMG00010051548
 protein coding gene Chr2:29221626-29238075 (+)
SPRET/EiJ ENSMSPG00010037536
 protein coding gene Chr2:29917397-29946654 (+)
WSB/EiJ ENSIUOG00005050503
 protein coding gene Chr2:29190334-29206757 (+)



Homology
more
  • Human Ortholog
    CIZ1, CDKN1A interacting zinc finger protein 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CIZ1, CDKN1A interacting zinc finger protein 1
  • Synonyms
    LSFR1, NP94, ZNF356
  • Links
    NCBI Gene ID: 25792
    UniProt: Q9ULV3

  • Chr Location
    9q34.11; chr9:128161251-128204482 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 2 alleles in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased body size and sex specific effects on motor phenotypes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    944
  • Tissues
    104
  • cDNA Data
    11
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 68379 NCBI Gene Model | MGI Sequence Detail 15588 C57BL/6J ±  kb
    transcript NM_001252534 RefSeq | MGI Sequence Detail 3116 C57BL/6  
    polypeptide NP_082688 RefSeq | MGI Sequence Detail 845 C57BL/6  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      18 Sequences
    • InterPro Domains
      IPR026811 Cip1-interacting zinc finger protein
      IPR056345 CIZ1, C2H2-type zinc finger
      IPR000690 Matrin/U1-C, C2H2-type zinc finger
      IPR003604 Matrin/U1-C-like, C2H2-type zinc finger
      IPR036236 Zinc finger C2H2 superfamily
      IPR013087 Zinc finger C2H2-type
      IPR022755 Zinc finger, double-stranded RNA binding
    • GlyGen
      Q8VEH2 2 sites
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 13
      Primer pair 6
      Antibodies 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1915629
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 4
      Gene Ontology 8
      Phenotypes 14
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:390682 Dobbs OG, et al., Epigenetic instability caused by absence of CIZ1 drives transformation during quiescence cycles. BMC Biol. 2023 Aug 15;21(1):175
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory