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Mblac2 Gene Detail
Summary
  • Symbol
    Mblac2
  • Name
    metallo-beta-lactamase domain containing 2
  • Synonyms
    2900024O10Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920102
    NCBI Gene: 72852
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:81859536-81901394 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 43.68 cM, cytoband C3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1207 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1920102
 protein coding gene Chr13:81859460-81901394 (+)
129S1/SvImJ ENSMUSG00200005793
 protein coding gene Chr13:76300506-76342432 (+)
A/J ENSMUSG00195024980
 protein coding gene Chr13:76810997-76846789 (+)
AKR/J ENSMUSG00220016415
 protein coding gene Chr13:75357513-75399447 (+)
BALB/cJ ENSMUSG00180001413
 protein coding gene Chr13:77313714-77349489 (+)
C3H/HeJ ENSMUSG00175019053
 protein coding gene Chr13:77559122-77601050 (+)
C57BL/6NJ ENSMUSG00215002506
 protein coding gene Chr13:77439121-77481060 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018746
 protein coding gene Chr13:76075601-76108739 (+)
CAST/EiJ ENSTCUG00005003684
 protein coding gene Chr13:76795357-76831633 (+)
CBA/J ENSMUSG00210005517
 protein coding gene Chr13:76849160-76891092 (+)
DBA/2J ENSMUSG00185016993
 protein coding gene Chr13:80529390-80571325 (+)
FVB/NJ ENSMUSG00205011907
 protein coding gene Chr13:76297218-76339141 (+)
JF1/MsJ ENSUMUG00000024248
 protein coding gene Chr13:80310695-80347741 (+)
LP/J ENSMUSG00230003546
 protein coding gene Chr13:90514559-90556488 (+)
NOD/ShiLtJ ENSMUSG00190008226
 protein coding gene Chr13:76864119-76906029 (+)
NZO/HlLtJ ENSMUSG00225030130
 protein coding gene Chr13:83033004-83074932 (+)
PWK/PhJ ENSLUMG00010014224
 protein coding gene Chr13:76423936-76459722 (+)
SPRET/EiJ ENSMSPG00010001237
 protein coding gene Chr13:77317398-77349311 (+)
WSB/EiJ ENSIUOG00005017372
 protein coding gene Chr13:76146812-76182557 (+)



Homology
more
  • Human Ortholog
    MBLAC2, metallo-beta-lactamase domain containing 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MBLAC2, metallo-beta-lactamase domain containing 2
  • Links
    NCBI Gene ID: 153364
    UniProt: Q68D91

  • Chr Location
    5q14.3; chr5:90458209-90474771 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotype references
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    1
  • Gene trapped
    1
  • Targeted
    2
  • Genomic Mutations
    1 involving Mblac2
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
    14 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    602
  • Tissues
    3
  • cDNA Data
    6
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 72852 NCBI Gene Model | MGI Sequence Detail 41859 C57BL/6J ±  kb
transcript NM_028372 RefSeq | MGI Sequence Detail 3881 C57BL/6  
polypeptide Q8BL86 UniProt | EBI | MGI Sequence Detail 279 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 8
    Genomic 2
    cDNA 6

    Microarray probesets 3
References
more
  • Summaries
    All 35
    Developmental Gene Expression 2
    Gene Ontology 6
    Phenotypes 10
  • Earliest
    J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
  • Latest
    J:375694 Lechner S, et al., Serendipitous and Systematic Chemoproteomic Discovery of MBLAC2, HINT1, and NME1-4 Inhibitors from Histone Deacetylase-Targeting Pharmacophores. ACS Chem Biol. 2025 Jun 20;20(6):1247-1257
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory