Tmem135 MGI Mouse Gene Detail - MGI:1920009

Symbol

Tmem135
Name

transmembrane protein 135
Synonyms

2810439K08Rik

Feature Type

protein coding gene
IDs

MGI:1920009
NCBI Gene: 72759
Alliance

genome feature page
Transcription Start Sites

13 TSS

Sequence Map

Chr7:88788922-89053430 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 49.32 cM, cytoband E1
Mapping Data

3 experiments

SNPs within 2kb

5848 from dbSNP Build 142
Strain Annotations

17

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1920009	protein coding gene	Chr7:88788922-89053911 (-)
129S1/SvImJ	ENSMUSG00200025899	protein coding gene	Chr7:75594281-75791883 (-)
A/J	ENSMUSG00195038784	protein coding gene	Chr7:80117017-80316119 (-)
AKR/J	ENSMUSG00220041030	protein coding gene	Chr7:73587309-73786447 (-)
BALB/cJ	ENSMUSG00180035963	protein coding gene	Chr7:76793959-76993081 (-)
C3H/HeJ	ENSMUSG00175033391	protein coding gene	Chr7:77482657-77680250 (-)
C57BL/6NJ	ENSMUSG00215026613	protein coding gene	Chr7:76624478-76823558 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029972	protein coding gene	Chr7:92288741-92537755 (-)
CAST/EiJ	no annotation
CBA/J	ENSMUSG00210035778	protein coding gene	Chr7:77324635-77522238 (-)
DBA/2J	ENSMUSG00185030699	protein coding gene	Chr7:81654179-81851772 (-)
FVB/NJ	ENSMUSG00205028455	protein coding gene	Chr7:77272088-77471199 (-)
JF1/MsJ	no annotation
LP/J	ENSMUSG00230014818	protein coding gene	Chr7:87743778-87941370 (-)
NOD/ShiLtJ	ENSMUSG00190024465	protein coding gene	Chr7:77538093-77737185 (-)
NZO/HlLtJ	ENSMUSG00225010592	protein coding gene	Chr7:86018442-86216041 (-)
PWK/PhJ	ENSLUMG00010033022	protein coding gene	Chr7:75763372-75969148 (-)
SPRET/EiJ	ENSMSPG00010012411	protein coding gene	Chr7:76837201-77030948 (-)
WSB/EiJ	ENSIUOG00005033563	protein coding gene	Chr7:77877143-78076147 (-)

Human Ortholog

TMEM135, transmembrane protein 135

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TMEM135, transmembrane protein 135
Synonyms

PMP52
Links

HGNC:26167

NCBI Gene ID: 65084

UniProt: Q86UB9
Chr Location

11q14.2; chr11:87037831-87328824 (+) GRCh38

MGI Vertebrate Homology

Tmem135 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TMEM135
Gene Tree

Tmem135

less

Phenotype Summary

19 phenotypes from 3 alleles in 3 genetic backgrounds
11 phenotypes from multigenic genotypes
44 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

26
Chemically induced (ENU)

1
Chemically induced (other)

1
Endonuclease-mediated

8
Gene trapped

8
Radiation induced

3
Targeted

4
Transgenic

1
Genomic Mutations

4 involving Tmem135
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

52 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for an ENU-induced allele exhibit age-dependent retinal pathologies and progressive sensorineural hearing loss.

less

All GO Annotations

26
GO References

9

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

597
cDNA Data

83

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tmem135

less

All Sequences

70
RefSeq

20
UniProt

4
CCDS

CCDS21440.1

Ensembl

ENSMUSG00000039428 (Evidence)
NCBI Gene

72759

			Length	Strain/Species	Flank
genomic	ENSMUSG00000039428	Ensembl Gene Model \| MGI Sequence Detail	264509	C57BL/6J	± kb
transcript	ENSMUST00000041968	Ensembl \| MGI Sequence Detail	3700	Not Applicable
polypeptide	ENSMUSP00000042783	Ensembl \| MGI Sequence Detail	458	Not Applicable

less

UniProt

4 Sequences
Protein Ontology

PR:000030652 transmembrane protein 135

(term hierarchy)
InterPro Domains

IPR026749 Transmembrane protein 135

IPR031926 Transmembrane protein 135, N-terminal domain
GlyGen

Q9CYV5 1 site, 1 O-linked glycan (1 site)

less

All nucleic 83

cDNA 83

Microarray probesets 4

less

MGI:2142228

Summaries

All 73

Gene Ontology 9

Phenotypes 44
Earliest

J:141526 Russell LB, et al., Analysis of the albino-locus region of the mouse. III. Time of death of prenatal lethals. Genetics. 1979 May;92(1):205-13
Latest

J:364559 Kim MJ, et al., A mutation in Tmem135 causes progressive sensorineural hearing loss. Hear Res. 2025 Apr;459:109221

TSS for Tmem135:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr73482	Chr7:89053418-89053445 (-)	-2 bp
Tssr73481	Chr7:89053399-89053412 (-)	24 bp
Tssr73480	Chr7:89053352-89053357 (-)	75 bp
Tssr73479	Chr7:88988120-88988127 (-)	65,306 bp
Tssr73478	Chr7:88987917-88988003 (-)	65,470 bp
Tssr73477	Chr7:88987893-88987913 (-)	65,527 bp
Tssr73476	Chr7:88987877-88987888 (-)	65,547 bp
Tssr73475	Chr7:88987854-88987874 (-)	65,566 bp
Tssr73474	Chr7:88987813-88987840 (-)	65,603 bp
Tssr73473	Chr7:88987797-88987808 (-)	65,627 bp
Tssr73472	Chr7:88977932-88977935 (-)	75,496 bp
Tssr73471	Chr7:88838922-88838929 (-)	214,504 bp
Tssr73470	Chr7:88837518-88837523 (-)	215,909 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24