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Zup1 Gene Detail
Summary
  • Symbol
    Zup1
  • Name
    zinc finger containing ubiquitin peptidase 1
  • Synonyms
    2700019D07Rik, Zufsp
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919830
    NCBI Gene: 72580
  • Alliance
    genome feature page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:33795138-33827265 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 18.85 cM, cytoband B1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    989 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919830
 protein coding gene Chr10:33795138-33827316 (-)
129S1/SvImJ ENSMUSG00200008575
 protein coding gene Chr10:30639905-30672036 (-)
A/J ENSMUSG00195016077
 protein coding gene Chr10:30916016-30948148 (-)
AKR/J ENSMUSG00220026800
 protein coding gene Chr10:30613249-30645377 (-)
BALB/cJ ENSMUSG00180014888
 protein coding gene Chr10:31036043-31068178 (-)
C3H/HeJ ENSMUSG00175011557
 protein coding gene Chr10:30791054-30823183 (-)
C57BL/6NJ ENSMUSG00215007917
 protein coding gene Chr10:30580709-30612829 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015225
 protein coding gene Chr10:29758123-29783211 (-)
CAST/EiJ ENSTCUG00005028175
 protein coding gene Chr10:31028977-31061196 (-)
CBA/J ENSMUSG00210025174
 protein coding gene Chr10:30718439-30750567 (-)
DBA/2J ENSMUSG00185007336
 protein coding gene Chr10:30871263-30903388 (-)
FVB/NJ ENSMUSG00205012575
 protein coding gene Chr10:30852062-30884192 (-)
JF1/MsJ ENSUMUG00000033056
 protein coding gene Chr10:30629216-30661284 (-)
LP/J ENSMUSG00230015048
 protein coding gene Chr10:32636827-32668956 (-)
NOD/ShiLtJ ENSMUSG00190026906
 protein coding gene Chr10:30984276-31016395 (-)
NZO/HlLtJ ENSMUSG00225033073
 protein coding gene Chr10:36895185-36927313 (-)
PWK/PhJ ENSLUMG00010007327
 protein coding gene Chr10:30647401-30679394 (-)
SPRET/EiJ ENSMSPG00010020123
 protein coding gene Chr10:31591616-31623958 (-)
WSB/EiJ ENSIUOG00005014850
 protein coding gene Chr10:30418568-30450715 (-)



Homology
more
  • Human Ortholog
    ZUP1, zinc finger containing ubiquitin peptidase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ZUP1, zinc finger containing ubiquitin peptidase 1
  • Synonyms
    C6orf113, DUB, ZUFSP
  • Links
    NCBI Gene ID: 221302
    UniProt: Q96AP4

  • Chr Location
    6q22.1; chr6:116635616-116668812 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display increased susceptibility to RNA virus infection.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    605
  • Tissues
    8
  • cDNA Data
    50
  • Literature Summary
    1
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000039531 Ensembl Gene Model | MGI Sequence Detail 32128 C57BL/6J ±  kb
transcript ENSMUST00000218055 Ensembl | MGI Sequence Detail 2180 Not Applicable  
polypeptide ENSMUSP00000151811 Ensembl | MGI Sequence Detail 577 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 51
    cDNA 50
    Primer pair 1

    Microarray probesets 2
Other
Accession IDs
less
MGI:6156406
References
more
  • Summaries
    All 43
    Developmental Gene Expression 1
    Gene Ontology 7
    Phenotypes 15
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:350802 Li T, et al., MAVS promotes interferon signaling in RNA virus infection by ZUFSP-mediated chromatin regulation. Int Immunopharmacol. 2024 Mar 8;131:111819
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory