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Tagap1 Gene Detail
Summary
  • Symbol
    Tagap1
  • Name
    T cell activation GTPase activating protein 1
  • Synonyms
    2610315E15Rik
Location &
Maps
more
  • Sequence Map
    Chr17:7222410-7228555 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 4.55 cM, cytoband A1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    106 from dbSNP Build 142
  • Strain Annotations
    11
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919786
 protein coding gene Chr17:7222364-7246122 (-)
129S1/SvImJ no annotation
A/J ENSMUSG00195022423
 protein coding gene Chr17:3669257-3675424 (-)
AKR/J no annotation
BALB/cJ no annotation
C3H/HeJ ENSMUSG00175032716
 protein coding gene Chr17:3459891-3466058 (-)
C57BL/6NJ ENSMUSG00215018462
 protein coding gene Chr17:3721926-3728071 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021039
 protein coding gene Chr17:3933751-3941819 (-)
CAST/EiJ ENSTCUG00005020299
 protein coding gene Chr17:3657587-3663724 (-)
CBA/J no annotation
DBA/2J ENSMUSG00185023163
 protein coding gene Chr17:4219393-4225559 (-)
FVB/NJ ENSMUSG00205008008
 protein coding gene Chr17:3784712-3790878 (-)
JF1/MsJ ENSUMUG00000029300
 protein coding gene Chr17:3797712-3810676 (-)
LP/J ENSMUSG00230031453
 protein coding gene Chr17:5611769-5617934 (-)
NOD/ShiLtJ ENSMUSG00190030395
 protein coding gene Chr17:4533703-4536488 (+)
NZO/HlLtJ no annotation
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    TAGAP, T cell activation RhoGTPase activating protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TAGAP, T cell activation RhoGTPase activating protein
  • Synonyms
    ARHGAP47, FKSG15, IDDM21, TAGAP1
  • Links
    NCBI Gene ID: 117289
    UniProt: Q8N103

  • Chr Location
    6q25.3; chr6:159034481-159095823 (-)  GRCh38
Human Diseases
less
  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    382 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
Molecular Function

Biological Process

Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000052031 Ensembl Gene Model | MGI Sequence Detail 6146 C57BL/6J ±  kb
    transcript ENSMUST00000063683 Ensembl | MGI Sequence Detail 2312 Not Applicable  
    polypeptide ENSMUSP00000070466 Ensembl | MGI Sequence Detail 505 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 5
      cDNA 5

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2146765
    References
    more
    • Summaries
      All 400
      Diseases 6
      Phenotypes 382
    • Earliest
      J:30229 Davisson MT, et al., Segmental trisomy as a mouse model for Down syndrome. Prog Clin Biol Res. 1993;384:117-33
    • Latest
      J:391449 Thibodeau J, et al., Loss of cystathionine-beta-synthase contributes to elevated OXPHOS, a vulnerability in Ara-C-resistant Myeloid Leukemia in Down syndrome. Biochem Pharmacol. 2026 Feb 13;247:117815
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory