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Iars2 Gene Detail
Summary
  • Symbol
    Iars2
  • Name
    isoleucine-tRNA synthetase 2, mitochondrial
  • Synonyms
    2010002H18Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919586
    NCBI Gene: 381314
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:185018839-185061615 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 89.48 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1101 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919586
 protein coding gene Chr1:185016923-185061615 (-)
129S1/SvImJ ENSMUSG00200021521
 protein coding gene Chr1:182796473-182837938 (-)
A/J ENSMUSG00195041265
 protein coding gene Chr1:182379636-182424244 (-)
AKR/J ENSMUSG00220019355
 protein coding gene Chr1:181605186-181646650 (-)
BALB/cJ ENSMUSG00180032608
 protein coding gene Chr1:182445855-182490460 (-)
C3H/HeJ ENSMUSG00175033334
 protein coding gene Chr1:182621351-182665957 (-)
C57BL/6NJ ENSMUSG00215023046
 protein coding gene Chr1:181833119-181877791 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015021
 protein coding gene Chr1:175144156-175189040 (-)
CAST/EiJ ENSTCUG00005040337
 protein coding gene Chr1:180391842-180433342 (-)
CBA/J ENSMUSG00210018969
 protein coding gene Chr1:182283117-182327787 (-)
DBA/2J ENSMUSG00185033396
 protein coding gene Chr1:186897764-186942434 (-)
FVB/NJ ENSMUSG00205032985
 protein coding gene Chr1:181313946-181358556 (-)
JF1/MsJ ENSUMUG00000003331
 protein coding gene Chr1:185898012-185939471 (-)
LP/J ENSMUSG00230022501
 protein coding gene Chr1:186457602-186500041 (-)
NOD/ShiLtJ ENSMUSG00190029089
 protein coding gene Chr1:182295555-182340162 (-)
NZO/HlLtJ ENSMUSG00225010608
 protein coding gene Chr1:190191710-190236381 (-)
PWK/PhJ ENSLUMG00010015251
 protein coding gene Chr1:181143604-181188212 (-)
SPRET/EiJ ENSMSPG00010021689
 protein coding gene Chr1:184646335-184687909 (-)
WSB/EiJ ENSIUOG00005010334
 protein coding gene Chr1:181489157-181533790 (-)



Homology
more
  • Human Ortholog
    IARS2, isoleucyl-tRNA synthetase 2, mitochondrial
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IARS2, isoleucyl-tRNA synthetase 2, mitochondrial
  • Synonyms
    CAGSSS, ILERS
  • Links
    NCBI Gene ID: 55699
    UniProt: Q9NSE4

  • Chr Location
    1q41; chr1:220094107-220148041 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    692
  • Tissues
    95
  • cDNA Data
    22
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 381314 NCBI Gene Model | MGI Sequence Detail 42777 C57BL/6J ±  kb
    transcript NM_198653 RefSeq | MGI Sequence Detail 3560 C57BL/6  
    polypeptide Q8BIJ6 UniProt | EBI | MGI Sequence Detail 1012 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000008877 isoleucine--tRNA ligase, mitochondrial
      (term hierarchy)
    • EC
      6.1.1.5
    • InterPro Domains
      IPR002300 Aminoacyl-tRNA synthetase, class Ia
      IPR009080 Aminoacyl-tRNA synthetase, class Ia, anticodon-binding
      IPR001412 Aminoacyl-tRNA synthetase, class I, conserved site
      IPR050081 Isoleucine--tRNA ligase
      IPR002301 Isoleucine-tRNA ligase
      IPR023585 Isoleucine-tRNA ligase, type 1
      IPR033708 Isoleucyl tRNA synthetase type 1, anticodon-binding domain
      IPR013155 Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding
      IPR014729 Rossmann-like alpha/beta/alpha sandwich fold
      IPR009008 Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain
      IPR010663 Zinc finger, FPG/IleRS-type
    • GlyGen
      Q8BIJ6 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 22
      cDNA 22

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2138678
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 2
      Gene Ontology 12
      Phenotypes 10
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory