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Tmem123 Gene Detail
Summary
  • Symbol
    Tmem123
  • Name
    transmembrane protein 123
  • Synonyms
    2310075C12Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919179
    NCBI Gene: 71929
  • Alliance
    genome feature page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:7764078-7794334 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 2.46 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1069 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919179
 protein coding gene Chr9:7764042-7794334 (+)
129S1/SvImJ ENSMUSG00200022372
 protein coding gene Chr9:4648173-4678459 (+)
A/J ENSMUSG00195018565
 protein coding gene Chr9:4526942-4557239 (+)
AKR/J ENSMUSG00220018569
 protein coding gene Chr9:4698229-4728521 (+)
BALB/cJ ENSMUSG00180011530
 protein coding gene Chr9:4664847-4695142 (+)
C3H/HeJ ENSMUSG00175023384
 protein coding gene Chr9:4583894-4614187 (+)
C57BL/6NJ ENSMUSG00215006072
 protein coding gene Chr9:4600634-4630934 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031760
 protein coding gene Chr9:3976695-4007338 (+)
CAST/EiJ ENSTCUG00005007118
 protein coding gene Chr9:4666466-4696185 (+)
CBA/J ENSMUSG00210010777
 protein coding gene Chr9:4615503-4645798 (+)
DBA/2J ENSMUSG00185005075
 protein coding gene Chr9:4732825-4763118 (+)
FVB/NJ ENSMUSG00205006926
 protein coding gene Chr9:4712706-4743001 (+)
JF1/MsJ ENSUMUG00000005998
 protein coding gene Chr9:4775713-4806257 (+)
LP/J ENSMUSG00230004261
 protein coding gene Chr9:5195841-5226131 (+)
NOD/ShiLtJ ENSMUSG00190021313
 protein coding gene Chr9:4636307-4666598 (+)
NZO/HlLtJ ENSMUSG00225016590
 protein coding gene Chr9:5072423-5102716 (+)
PWK/PhJ ENSLUMG00010006287
 protein coding gene Chr9:4736227-4766607 (+)
SPRET/EiJ ENSMSPG00010005485
 protein coding gene Chr9:4797112-4827001 (+)
WSB/EiJ ENSIUOG00005007444
 protein coding gene Chr9:4532978-4563252 (+)



Homology
more
  • Human Ortholog
    TMEM123, transmembrane protein 123
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TMEM123, transmembrane protein 123
  • Synonyms
    KCT3, PORIMIN, PORMIN
  • Links
    NCBI Gene ID: 114908
    UniProt: Q8N131

  • Chr Location
    11q22.2; chr11:102396332-102470384 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    11 phenotype references
Mice homozygous for a knock-out allele exhibit no abnormal phenotype as revealed by limited studies of T cell activation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    3
  • GO References
    3
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    599
  • Tissues
    2
  • cDNA Data
    210
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 71929 NCBI Gene Model | MGI Sequence Detail 30257 C57BL/6J ±  kb
transcript NR_152989 RefSeq | MGI Sequence Detail 2909 C57BL/6  
polypeptide Q91Z22 UniProt | EBI | MGI Sequence Detail 195 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 210
    cDNA 210

    Microarray probesets 4
References
more
  • Summaries
    All 36
    Developmental Gene Expression 1
    Gene Ontology 3
    Phenotypes 11
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory