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Csl Gene Detail
Summary
  • Symbol
    Csl
  • Name
    citrate synthase like
  • Synonyms
    1700007H16Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919082
    NCBI Gene: 71832
  • Alliance
    genome feature page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:99593567-99595346 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 51.20 cM, cytoband C3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    160 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919082
 protein coding gene Chr10:99593567-99595520 (-)
129S1/SvImJ ENSMUSG00200019854
 protein coding gene Chr10:96105927-96107879 (-)
A/J ENSMUSG00195014283
 protein coding gene Chr10:96537063-96539015 (-)
AKR/J ENSMUSG00220024962
 protein coding gene Chr10:96061915-96063888 (-)
BALB/cJ ENSMUSG00180009084
 protein coding gene Chr10:96544794-96546747 (-)
C3H/HeJ ENSMUSG00175005837
 protein coding gene Chr10:96426763-96428717 (-)
C57BL/6NJ ENSMUSG00215005306
 protein coding gene Chr10:96128280-96130232 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015767
 protein coding gene Chr10:93321703-93323663 (-)
CAST/EiJ ENSTCUG00005005480
 protein coding gene Chr10:95789074-95791033 (-)
CBA/J ENSMUSG00210022650
 protein coding gene Chr10:96256630-96258586 (-)
DBA/2J ENSMUSG00185018510
 protein coding gene Chr10:96486855-96488807 (-)
FVB/NJ ENSMUSG00205003218
 protein coding gene Chr10:96165954-96167906 (-)
JF1/MsJ ENSUMUG00000020262
 protein coding gene Chr10:97895894-97897846 (-)
LP/J ENSMUSG00230020650
 protein coding gene Chr10:98405427-98407379 (-)
NOD/ShiLtJ ENSMUSG00190022779
 protein coding gene Chr10:96504616-96506570 (-)
NZO/HlLtJ ENSMUSG00225040336
 protein coding gene Chr10:102636426-102638378 (-)
PWK/PhJ ENSLUMG00010005295
 protein coding gene Chr10:96155742-96157694 (-)
SPRET/EiJ ENSMSPG00010009114
 protein coding gene Chr10:97883623-97885489 (-)
WSB/EiJ ENSIUOG00005012692
 protein coding gene Chr10:96203809-96205755 (-)



Homology
more
  • Human Ortholog
    CS, citrate synthase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CS, citrate synthase
  • Links
    NCBI Gene ID: 1431
    UniProt: O75390

  • Chr Location
    12q13.3; chr12:56271699-56300391 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human CS associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Male mice homozygous for a knock-out allele are initially fertile but show an age-dependent decline in fertility and a delay in the first spike of Ca2+ oscillation during egg activation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    732
  • Tissues
    97
  • cDNA Data
    9
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 71832 NCBI Gene Model | MGI Sequence Detail 1780 C57BL/6J ±  kb
    transcript NM_027945 RefSeq | MGI Sequence Detail 1780 C57BL/6  
    polypeptide NP_082221 RefSeq | MGI Sequence Detail 466 C57BL/6  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • InterPro Domains
      IPR002020 Citrate synthase
      IPR019810 Citrate synthase active site
      IPR010109 Citrate synthase, eukaryotic-type
      IPR016142 Citrate synthase-like, large alpha subdomain
      IPR016143 Citrate synthase-like, small alpha subdomain
      IPR036969 Citrate synthase superfamily
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 9

      Microarray probesets 2
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 3
      Gene Ontology 7
      Phenotypes 15
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:379977 Horiike S, et al., Biological significance of sperm-independent calcium oscillations in immature oocytes of mice. MicroPubl Biol. 2025;2025
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    09/15/2026
    MGI 6.29     		The Jackson Laboratory