About   Help   FAQ
Ythdf3 Gene Detail
Summary
  • Symbol
    Ythdf3
  • Name
    YTH N6-methyladenosine RNA binding protein 3
  • Synonyms
    9130022A11Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918850
    NCBI Gene: 229096
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:16237376-16271201 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 4.04 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    736 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918850
 protein coding gene Chr3:16237309-16271201 (+)
129S1/SvImJ ENSMUSG00200018144
 protein coding gene Chr3:12984831-13018736 (+)
A/J ENSMUSG00195014850
 protein coding gene Chr3:13034194-13068079 (+)
AKR/J ENSMUSG00220008622
 protein coding gene Chr3:13038625-13072538 (+)
BALB/cJ ENSMUSG00180000979
 protein coding gene Chr3:13060393-13094276 (+)
C3H/HeJ ENSMUSG00175003038
 protein coding gene Chr3:13057392-13091276 (+)
C57BL/6NJ ENSMUSG00215001229
 protein coding gene Chr3:13298288-13332193 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024863
 protein coding gene Chr3:11675800-11705499 (+)
CAST/EiJ ENSTCUG00005024117
 protein coding gene Chr3:13067967-13101762 (+)
CBA/J ENSMUSG00210001590
 protein coding gene Chr3:13023841-13057723 (+)
DBA/2J ENSMUSG00185000597
 protein coding gene Chr3:13187769-13221669 (+)
FVB/NJ ENSMUSG00205002332
 protein coding gene Chr3:12587702-12621585 (+)
JF1/MsJ ENSUMUG00000015041
 protein coding gene Chr3:12876629-12909543 (+)
LP/J ENSMUSG00230004373
 protein coding gene Chr3:15188467-15222372 (+)
NOD/ShiLtJ ENSMUSG00190002087
 protein coding gene Chr3:13368747-13402652 (+)
NZO/HlLtJ ENSMUSG00225000609
 protein coding gene Chr3:17778924-17812845 (+)
PWK/PhJ ENSLUMG00010003058
 protein coding gene Chr3:12960687-12993948 (+)
SPRET/EiJ ENSMSPG00010001830
 protein coding gene Chr3:12843113-12877115 (+)
WSB/EiJ ENSIUOG00005001439
 protein coding gene Chr3:13287071-13320951 (+)



Homology
more
  • Human Ortholog
    YTHDF3, YTH N6-methyladenosine RNA binding protein F3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    YTHDF3, YTH N6-methyladenosine RNA binding protein F3
  • Synonyms
    DF3
  • Links
    NCBI Gene ID: 253943
    UniProt: Q7Z739

  • Chr Location
    8q12.3; chr8:63168553-63212788 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    7 phenotypes from multigenic genotypes
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased susceptibility to vesicular stomatitis virus (VSV) infection. Homozygous KO does not affect viability or fertility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    46
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    605
  • Tissues
    5
  • cDNA Data
    173
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000047213 Ensembl Gene Model | MGI Sequence Detail 33826 C57BL/6J ±  kb
    transcript ENSMUST00000108346 Ensembl | MGI Sequence Detail 4929 Not Applicable  
    polypeptide ENSMUSP00000103983 Ensembl | MGI Sequence Detail 596 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000029879 YTH domain-containing family protein 3
      (term hierarchy)
    • InterPro Domains
      IPR007275 YTH domain
      IPR045168 YTH domain containing protein
    • GlyGen
      Q8BYK6 9 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (7 sites)
    Molecular
    Reagents
    less
    • All nucleic 175
      cDNA 173
      Primer pair 1
      Other 1

      Microarray probesets 8
    References
    more
    • Summaries
      All 54
      Developmental Gene Expression 9
      Diseases 1
      Gene Ontology 9
      Phenotypes 18
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:386421 Jeon S, et al., Maternal immune activation perturbs the brain epitranscriptome. Brain Behav Immun. 2026 May 12;137:106804
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory