Depp1 MGI Mouse Gene Detail - MGI:1918730 - DEPP1 autophagy regulator

Symbol

Depp1
Name

DEPP1 autophagy regulator
Synonyms

8430408G22Rik, Depp

Feature Type

protein coding gene
IDs

MGI:1918730
NCBI Gene: 213393
Alliance

genome feature page
Transcription Start Sites

9 TSS

Sequence Map

Chr6:116627645-116629808 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 53.83 cM
Mapping Data

1 experiment

SNPs within 2kb

272 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1918730	protein coding gene	Chr6:116627570-116629808 (+)
129S1/SvImJ	ENSMUSG00200048067	protein coding gene	Chr6:113852464-113854680 (+)
A/J	ENSMUSG00195037310	protein coding gene	Chr6:113234324-113236510 (+)
AKR/J	ENSMUSG00220035032	protein coding gene	Chr6:112132573-112134789 (+)
BALB/cJ	ENSMUSG00180041504	protein coding gene	Chr6:113602050-113604236 (+)
C3H/HeJ	ENSMUSG00175028370	protein coding gene	Chr6:63853831-63856022 (-)
C57BL/6NJ	ENSMUSG00215047224	protein coding gene	Chr6:113591893-113594079 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028778	protein coding gene	Chr6:111771801-111773977 (+)
CAST/EiJ	ENSTCUG00005048888	protein coding gene	Chr6:113454221-113456426 (+)
CBA/J	ENSMUSG00210032753	protein coding gene	Chr6:113381376-113383567 (+)
DBA/2J	ENSMUSG00185048291	protein coding gene	Chr6:114045910-114048126 (+)
FVB/NJ	ENSMUSG00205025556	protein coding gene	Chr6:112543649-112545867 (+)
JF1/MsJ	ENSUMUG00000024726	protein coding gene	Chr6:112669938-112672129 (+)
LP/J	ENSMUSG00230044905	protein coding gene	Chr6:115250094-115252310 (+)
NOD/ShiLtJ	ENSMUSG00190043943	protein coding gene	Chr6:113000004-113002220 (+)
NZO/HlLtJ	ENSMUSG00225045669	protein coding gene	Chr6:117105873-117108089 (+)
PWK/PhJ	ENSLUMG00010026181	protein coding gene	Chr6:112038085-112040276 (+)
SPRET/EiJ	ENSMSPG00010036437	protein coding gene	Chr6:114845683-114847619 (+)
WSB/EiJ	ENSIUOG00005035513	protein coding gene	Chr6:113685203-113687421 (+)

Human Ortholog

DEPP1, DEPP autophagy regulator 1

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DEPP1, DEPP autophagy regulator 1
Synonyms

C10orf10, DEPP, FIG, Fseg
Links

HGNC:23355

NCBI Gene ID: 11067

UniProt: Q9NTK1
Chr Location

10q11.21; chr10:44970981-44978809 (-) GRCh38

MGI Vertebrate Homology

Depp1 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: DEPP1
Gene Tree

Depp1

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Phenotype Summary

8 phenotypes from 2 alleles in 2 genetic backgrounds
1 phenotype from multigenic genotypes
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Endonuclease-mediated

5
Targeted

1
Incidental Mutations

CvDC
Find Mice (IMSR)

20 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Male mice homozygous for a knock-out allele show exacerbated diet-induced obesity, increased adiposity and impaired glucose homeostasis on a high-fat diet. Mice homozygous for a knock-in allele are viable and fertile and display normal heart and blood vessel development.

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All GO Annotations

18
GO References

6

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

634
Tissues

37
cDNA Data

71
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

42
RefSeq

4
UniProt

2
CCDS

CCDS51882.1

Ensembl

ENSMUSG00000048489 (Evidence)
NCBI Gene

213393

			Length	Strain/Species	Flank
genomic	213393	NCBI Gene Model \| MGI Sequence Detail	2164	C57BL/6J	± kb
transcript	NM_145980	RefSeq \| MGI Sequence Detail	1317	C57BL/6
polypeptide	Q8K2F3	UniProt \| EBI \| MGI Sequence Detail	205	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000006421 protein DEPP1

(term hierarchy)
InterPro Domains

IPR020133 Decidual protein, progesterone induced

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All nucleic 71

cDNA 71

Microarray probesets 4

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MGI:6156099

Summaries

All 37

Developmental Gene Expression 5

Gene Ontology 6

Phenotypes 6
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:389887 Sheybani-Deloui S, et al., Loss of the calorie restriction response protein DEPP1 worsens diet-induced obesity. Endocrinology. 2026 Jul 8;167(8)

TSS for Depp1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr58374	Chr6:116627574-116627579 (+)	-68 bp
Tssr58375	Chr6:116627584-116627589 (+)	-58 bp
Tssr1978	Chr6:116627593-116627602 (+)	-47 bp
Tssr58376	Chr6:116627622-116627627 (+)	-20 bp
Tssr58377	Chr6:116627635-116627651 (+)	-2 bp
Tssr58378	Chr6:116627686-116627690 (+)	43 bp
Tssr58379	Chr6:116628740-116628757 (+)	1,104 bp
Tssr58380	Chr6:116628837-116628846 (+)	1,197 bp
Tssr58381	Chr6:116629191-116629224 (+)	1,563 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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