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Rassf8 Gene Detail
Summary
  • Symbol
    Rassf8
  • Name
    Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
  • Synonyms
    5133400D11Rik, mHoj-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918573
    NCBI Gene: 71323
  • Alliance
    genome feature page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:145692474-145766805 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 77.68 cM, cytoband G3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2276 from dbSNP Build 142
  • Strain Annotations
    27
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918573
 protein coding gene Chr6:145692292-145766805 (+)
129S1/SvImJ ENSMUSG00200003401
 protein coding gene Chr6:143308598-143309728 (+)
129S1/SvImJ ENSMUSG00200003387
 protein coding gene Chr6:143237368-143308176 (+)
A/J ENSMUSG00195007887
 protein coding gene Chr6:142214867-142215997 (+)
A/J ENSMUSG00195007873
 protein coding gene Chr6:142143628-142214445 (+)
AKR/J ENSMUSG00220029189
 protein coding gene Chr6:140382579-140460953 (+)
BALB/cJ ENSMUSG00180015480
 protein coding gene Chr6:142342066-142343196 (+)
BALB/cJ ENSMUSG00180015464
 protein coding gene Chr6:142270833-142341644 (+)
C3H/HeJ ENSMUSG00175002451
 protein coding gene Chr6:142183081-142261445 (+)
C57BL/6NJ ENSMUSG00215013295
 protein coding gene Chr6:142419461-142420591 (+)
C57BL/6NJ ENSMUSG00215013210
 protein coding gene Chr6:142346424-142419039 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029050
 protein coding gene Chr6:143544483-143616217 (+)
CAST/EiJ ENSTCUG00005010482
 protein coding gene Chr6:142982725-143053625 (+)
CBA/J ENSMUSG00210004341
 protein coding gene Chr6:142326954-142328084 (+)
CBA/J ENSMUSG00210004328
 protein coding gene Chr6:142253953-142326532 (+)
DBA/2J ENSMUSG00185015716
 protein coding gene Chr6:142895915-142974282 (+)
FVB/NJ ENSMUSG00205019663
 protein coding gene Chr6:141215014-141285836 (+)
FVB/NJ ENSMUSG00205019730
 protein coding gene Chr6:141286257-141287387 (+)
JF1/MsJ ENSUMUG00000004829
 protein coding gene Chr6:141558261-141627874 (+)
LP/J ENSMUSG00230005022
 protein coding gene Chr6:143998732-144069548 (+)
LP/J ENSMUSG00230005024
 protein coding gene Chr6:144069970-144071100 (+)
NOD/ShiLtJ ENSMUSG00190001537
 protein coding gene Chr6:142790995-142792125 (+)
NOD/ShiLtJ ENSMUSG00190001528
 protein coding gene Chr6:142719756-142790574 (+)
NZO/HlLtJ ENSMUSG00225012966
 protein coding gene Chr6:146886267-146966588 (+)
PWK/PhJ ENSLUMG00010032486
 protein coding gene Chr6:140644143-140713909 (+)
SPRET/EiJ ENSMSPG00010015030
 protein coding gene Chr6:144562894-144626839 (+)
WSB/EiJ ENSIUOG00005022080
 protein coding gene Chr6:142937221-143009562 (+)



Homology
more
  • Human Ortholog
    RASSF8, Ras association domain family member 8
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RASSF8, Ras association domain family member 8
  • Synonyms
    C12orf2, HOJ1
  • Links
    NCBI Gene ID: 11228
    UniProt: Q8NHQ8

  • Chr Location
    12p12.1; chr12:25958068-26079892 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    1
  • GO References
    1
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    702
  • Tissues
    53
  • cDNA Data
    10
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030259 Ensembl Gene Model | MGI Sequence Detail 74332 C57BL/6J ±  kb
    transcript ENSMUST00000111704 Ensembl | MGI Sequence Detail 5446 Not Applicable  
    polypeptide ENSMUSP00000107333 Ensembl | MGI Sequence Detail 419 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000031357 Ras association domain-containing protein 8
      (term hierarchy)
    • InterPro Domains
      IPR033593 N-terminal RASSF family
      IPR000159 Ras-associating domain
      IPR048945 Ras association domain-containing protein 8/10, RA domain
      IPR048944 Ras association domain-containing protein 8, RA domain
      IPR029071 Ubiquitin-like domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 10

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:2141651, MGI:3034889
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 6
      Gene Ontology 1
      Phenotypes 12
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory