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Mterf4 Gene Detail
Summary
  • Symbol
    Mterf4
  • Name
    mitochondrial transcription termination factor 4
  • Synonyms
    1810059A23Rik, 4933412H03Rik, Mterfd2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918355
    NCBI Gene: 69821
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:93228927-93233601 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 47.24 cM, cytoband D
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    149 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918355
 protein coding gene Chr1:93226933-93233637 (-)
129S1/SvImJ ENSMUSG00200037734
 protein coding gene Chr1:90443200-90449904 (-)
A/J ENSMUSG00195031597
 protein coding gene Chr1:90002115-90008817 (-)
AKR/J ENSMUSG00220044059
 protein coding gene Chr1:90156841-90163543 (-)
BALB/cJ ENSMUSG00180015007
 protein coding gene Chr1:90319337-90326039 (-)
C3H/HeJ ENSMUSG00175001021
 protein coding gene Chr1:90197268-90203974 (-)
C57BL/6NJ ENSMUSG00215029792
 protein coding gene Chr1:90129453-90136157 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014452
 protein coding gene Chr1:85766048-85772697 (-)
CAST/EiJ ENSTCUG00005006845
 protein coding gene Chr1:89779785-89786483 (-)
CBA/J ENSMUSG00210012232
 protein coding gene Chr1:90042474-90049182 (-)
DBA/2J ENSMUSG00185013319
 protein coding gene Chr1:94515462-94522166 (-)
FVB/NJ ENSMUSG00205035306
 protein coding gene Chr1:89445053-89451757 (-)
JF1/MsJ ENSUMUG00000010996
 protein coding gene Chr1:93256495-93263187 (-)
LP/J ENSMUSG00230020579
 protein coding gene Chr1:93779303-93786007 (-)
NOD/ShiLtJ ENSMUSG00190022539
 protein coding gene Chr1:90087066-90093768 (-)
NZO/HlLtJ ENSMUSG00225002669
 protein coding gene Chr1:97678383-97685091 (-)
PWK/PhJ ENSLUMG00010040018
 protein coding gene Chr1:89642985-89649682 (-)
SPRET/EiJ ENSMSPG00010044627
 protein coding gene Chr1:91680999-91685697 (-)
WSB/EiJ ENSIUOG00005034736
 protein coding gene Chr1:89739641-89746341 (-)



Homology
more
  • Human Ortholog
    MTERF4, mitochondrial transcription termination factor 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MTERF4, mitochondrial transcription termination factor 4
  • Synonyms
    MTERFD2
  • Links
    NCBI Gene ID: 130916
    UniProt: Q7Z6M4

  • Chr Location
    2q37.3; chr2:241042586-241102332 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit complete embryonic lethality associated with decreased embryo size, lack of heart, and absence of optic discs.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    30
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    646
  • Tissues
    45
  • cDNA Data
    43
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 69821 NCBI Gene Model | MGI Sequence Detail 4675 C57BL/6J ±  kb
    transcript NM_178051 RefSeq | MGI Sequence Detail 1330 C57BL/6  
    polypeptide Q8BVN4 UniProt | EBI | MGI Sequence Detail 346 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 47
      cDNA 43
      Primer pair 2
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1917071
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 1
      Gene Ontology 9
      Phenotypes 11
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:285406 Busch JD, et al., MitoRibo-Tag Mice Provide a Tool for In Vivo Studies of Mitoribosome Composition. Cell Rep. 2019 Nov 5;29(6):1728-1738.e9
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory