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Hsfy2 Gene Detail
Summary
  • Symbol
    Hsfy2
  • Name
    heat shock transcription factor, Y-linked 2
  • Synonyms
    4933413G11Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918316
    NCBI Gene: 71066
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:56675203-56676594 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 28.72 cM, cytoband C1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    109 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918316
 protein coding gene Chr1:56675203-56676610 (-)
129S1/SvImJ ENSMUSG00200018630
 protein coding gene Chr1:54169758-54171149 (-)
A/J ENSMUSG00195028903
 protein coding gene Chr1:53711261-53712652 (-)
AKR/J ENSMUSG00220035387
 protein coding gene Chr1:53800028-53801419 (-)
BALB/cJ ENSMUSG00180014089
 protein coding gene Chr1:53957626-53959017 (-)
C3H/HeJ ENSMUSG00175000818
 protein coding gene Chr1:54088984-54090375 (-)
C57BL/6NJ ENSMUSG00215017948
 protein coding gene Chr1:54020389-54021780 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014149
 protein coding gene Chr1:50451235-50452627 (-)
CAST/EiJ ENSTCUG00005012593
 protein coding gene Chr1:53894621-53896012 (-)
CBA/J ENSMUSG00210054063
 protein coding gene Chr1:53769557-53770948 (-)
DBA/2J ENSMUSG00185039715
 protein coding gene Chr1:54889177-54890568 (-)
FVB/NJ ENSMUSG00205016848
 protein coding gene Chr1:53735922-53737313 (-)
JF1/MsJ ENSUMUG00000020009
 protein coding gene Chr1:53858631-53860022 (-)
LP/J ENSMUSG00230028745
 protein coding gene Chr1:54899855-54901246 (-)
NOD/ShiLtJ ENSMUSG00190026077
 protein coding gene Chr1:53948794-53950185 (-)
NZO/HlLtJ ENSMUSG00225007791
 protein coding gene Chr1:58096534-58097925 (-)
PWK/PhJ ENSLUMG00010025317
 protein coding gene Chr1:53388283-53389674 (-)
SPRET/EiJ ENSMSPG00010024297
 protein coding gene Chr1:55222276-55223667 (-)
WSB/EiJ ENSIUOG00005017795
 protein coding gene Chr1:53563401-53564792 (-)



Homology
more
  • Human Ortholog
    HSFY1, heat shock transcription factor Y-linked 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HSFY1, heat shock transcription factor Y-linked 1
  • Synonyms
    HSF2L, HSFY
  • Links
    NCBI Gene ID: 86614
    UniProt: Q96LI6

  • Chr Location
    Yq11.222; chrY:18529643-18588963 (+)  GRCh38
  • Human Ortholog
    HSFY2, heat shock transcription factor Y-linked 2
  • Synonyms
    HSF2L, HSFY
  • Links
    NCBI Gene ID: 159119
    UniProt: Q96LI6

  • Chr Location
    Yq11.222
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    691
  • Tissues
    94
  • cDNA Data
    10
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000045336 Ensembl Gene Model | MGI Sequence Detail 1392 C57BL/6J ±  kb
    transcript ENSMUST00000062085 Ensembl | MGI Sequence Detail 1392 Not Applicable  
    polypeptide ENSMUSP00000049715 Ensembl | MGI Sequence Detail 392 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • InterPro Domains
      IPR000232 Heat shock factor (HSF)-type, DNA-binding
      IPR036390 Winged helix DNA-binding domain superfamily
      IPR036388 Winged helix-like DNA-binding domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 10

      Microarray probesets 2
    References
    more
    • Summaries
      All 33
      Developmental Gene Expression 2
      Gene Ontology 4
      Phenotypes 10
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:347775 Yoshimura S, et al., Atypical heat shock transcription factor HSF5 is critical for male meiotic prophase under non-stress conditions. Nat Commun. 2024 Apr 29;15(1):3330
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory