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P2ry12 Gene Detail
Summary
  • Symbol
    P2ry12
  • Name
    purinergic receptor P2Y, G-protein coupled 12
  • Synonyms
    2900079B22Rik, 4921504D23Rik, P2Y12
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918089
    NCBI Gene: 70839
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:59123693-59170292 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 29.01 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1356 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918089
 protein coding gene Chr3:59123692-59170408 (-)
129S1/SvImJ ENSMUSG00200022613
 protein coding gene Chr3:56007101-56018417 (-)
A/J ENSMUSG00195031426
 protein coding gene Chr3:55917578-55928889 (-)
AKR/J ENSMUSG00220027496
 protein coding gene Chr3:55976765-55988080 (-)
BALB/cJ ENSMUSG00180025205
 protein coding gene Chr3:56002107-56013423 (-)
C3H/HeJ ENSMUSG00175008439
 protein coding gene Chr3:55843431-55854745 (-)
C57BL/6NJ ENSMUSG00215006851
 protein coding gene Chr3:56286891-56298200 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025019
 protein coding gene Chr3:52636364-52681878 (-)
CAST/EiJ ENSTCUG00005002340
 protein coding gene Chr3:55592664-55603975 (-)
CBA/J ENSMUSG00210003384
 protein coding gene Chr3:55959096-55970410 (-)
DBA/2J ENSMUSG00185026859
 protein coding gene Chr3:56127996-56139305 (-)
FVB/NJ ENSMUSG00205003233
 protein coding gene Chr3:55116766-55128080 (-)
JF1/MsJ ENSUMUG00000002347
 protein coding gene Chr3:55547421-55558687 (-)
LP/J ENSMUSG00230003494
 protein coding gene Chr3:58139137-58150451 (-)
NOD/ShiLtJ ENSMUSG00190025864
 protein coding gene Chr3:56315030-56326343 (-)
NZO/HlLtJ ENSMUSG00225017111
 protein coding gene Chr3:60750652-60761961 (-)
PWK/PhJ ENSLUMG00010004934
 protein coding gene Chr3:55648703-55660233 (-)
SPRET/EiJ ENSMSPG00010007236
 protein coding gene Chr3:56527264-56538575 (-)
WSB/EiJ ENSIUOG00005008482
 protein coding gene Chr3:56096524-56107835 (-)



Homology
more
  • Human Ortholog
    P2RY12, purinergic receptor P2Y12
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    P2RY12, purinergic receptor P2Y12
  • Synonyms
    ADPG-R, BDPLT8, HORK3, P2T(AC), P2Y12, P2Y(12)R, P2Y(AC), P2Y(ADP), P2Y(cyc), SP1999
  • Links
    NCBI Gene ID: 64805
    UniProt: Q9H244

  • Chr Location
    3q25.1; chr3:151336843-151384753 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with P2ry12 mouse models; 5 with human P2RY12 associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 3 alleles in 3 genetic backgrounds
    80 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in impaired platelet activation, increased bleeding time and delayed thrombus formation in injured arteries.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    63
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    650
  • Tissues
    20
  • cDNA Data
    14
  • Literature Summary
    28
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000036353 Ensembl Gene Model | MGI Sequence Detail 46600 C57BL/6J ±  kb
transcript ENSMUST00000196583 Ensembl | MGI Sequence Detail 2344 Not Applicable  
polypeptide ENSMUSP00000143036 Ensembl | MGI Sequence Detail 347 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 14
    cDNA 14
    Antibodies 4

    Microarray probesets 2
Other
Accession IDs
less
MGI:1920308
References
more
  • Summaries
    All 179
    Developmental Gene Expression 28
    Diseases 3
    Gene Ontology 12
    Phenotypes 80
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:391248 Luan P, et al., A reciprocal glial circuit calibrates injury information and governs the tissue response balance. Neuron. 2026 Apr 15;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory