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Zcchc8 Gene Detail
Summary
  • Symbol
    Zcchc8
  • Name
    zinc finger, CCHC domain containing 8
  • Synonyms
    5730565F05Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917900
    NCBI Gene: 70650
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:123836365-123859107 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 63.14 cM, cytoband F
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    710 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917900
 protein coding gene Chr5:123836357-123859163 (-)
129S1/SvImJ ENSMUSG00200024580
 protein coding gene Chr5:117552580-117575643 (-)
A/J ENSMUSG00195011850
 protein coding gene Chr5:117074044-117097109 (-)
AKR/J ENSMUSG00220036605
 protein coding gene Chr5:116591213-116614024 (-)
BALB/cJ ENSMUSG00180032638
 protein coding gene Chr5:117188992-117212055 (-)
C3H/HeJ ENSMUSG00175029182
 protein coding gene Chr5:119197494-119220306 (-)
C57BL/6NJ ENSMUSG00215026765
 protein coding gene Chr5:117244971-117267777 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027732
 protein coding gene Chr5:116701458-116726127 (-)
CAST/EiJ ENSTCUG00005036776
 protein coding gene Chr5:116483970-116507156 (-)
CBA/J ENSMUSG00210009068
 protein coding gene Chr5:117948250-117971061 (-)
DBA/2J ENSMUSG00185042418
 protein coding gene Chr5:120999511-121022321 (-)
FVB/NJ ENSMUSG00205042969
 protein coding gene Chr5:116874825-116897633 (-)
JF1/MsJ ENSUMUG00000015931
 protein coding gene Chr5:123861740-123884829 (-)
LP/J ENSMUSG00230044243
 protein coding gene Chr5:125074520-125097578 (-)
NOD/ShiLtJ ENSMUSG00190036880
 protein coding gene Chr5:116873894-116896704 (-)
NZO/HlLtJ ENSMUSG00225013949
 protein coding gene Chr5:132777816-132800622 (-)
PWK/PhJ ENSLUMG00010042061
 protein coding gene Chr5:115755979-115779041 (-)
SPRET/EiJ ENSMSPG00010042578
 protein coding gene Chr5:119068963-119091709 (-)
WSB/EiJ ENSIUOG00005014387
 protein coding gene Chr5:119580259-119603085 (-)



Homology
more
  • Human Ortholog
    ZCCHC8, zinc finger CCHC-type containing 8
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ZCCHC8, zinc finger CCHC-type containing 8
  • Synonyms
    PFBMFT5
  • Links
    NCBI Gene ID: 55596
    UniProt: Q6NZY4

  • Chr Location
    12q24.31; chr12:122471600-122500932 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 1 allele in 1 genetic background
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele show partial lethality by E17.5 and lower survival rate in the first 3 months, small body size, infertility, small testes and ovaries, loss of sperm, fewer mature ovarian follicles, and oocyte maturation defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    612
  • Tissues
    12
  • cDNA Data
    89
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 70650 NCBI Gene Model | MGI Sequence Detail 22743 C57BL/6J ±  kb
    transcript NM_027494 RefSeq | MGI Sequence Detail 4286 C57BL/6  
    polypeptide Q9CYA6 UniProt | EBI | MGI Sequence Detail 709 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000017608 zinc finger CCHC domain-containing protein 8
      (term hierarchy)
    • InterPro Domains
      IPR006568 PSP, proline-rich
      IPR052115 Zinc finger CCHC domain-containing protein 8
      IPR001878 Zinc finger, CCHC-type
    • GlyGen
      Q9CYA6 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 92
      cDNA 90
      Primer pair 1
      Other 1
      Antibodies 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 4
      Gene Ontology 6
      Phenotypes 14
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:385064 Pan Y, et al., Nuclear exosome targeting complex safeguards hematopoietic stem cell self-renewal and genomic integrity through resolving R loops. Cell Rep. 2025 Dec 6;44(12):116650
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    09/01/2026
    MGI 6.24     		The Jackson Laboratory