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Sis Gene Detail
Summary
  • Symbol
    Sis
  • Name
    sucrase isomaltase
  • Synonyms
    2010204N08Rik, Si-s, sucrase-isomaltase
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917233
    NCBI Gene: 69983
  • Alliance
    genome feature page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:72795890-72875196 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 32.59 cM
  • Mapping Data
    13 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1975 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917233
 protein coding gene Chr3:72795890-72875196 (-)
129S1/SvImJ ENSMUSG00200001507
 protein coding gene Chr3:69553792-69628948 (-)
A/J ENSMUSG00195026301
 protein coding gene Chr3:69648638-69723810 (-)
AKR/J ENSMUSG00220024592
 protein coding gene Chr3:69650943-69726130 (-)
BALB/cJ ENSMUSG00180008219
 protein coding gene Chr3:69728672-69803833 (-)
C3H/HeJ ENSMUSG00175003501
 protein coding gene Chr3:69592272-69664952 (-)
C57BL/6NJ ENSMUSG00215005232
 protein coding gene Chr3:70017010-70096324 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025072
 protein coding gene Chr3:66131666-66202514 (-)
CAST/EiJ ENSTCUG00005021814
 protein coding gene Chr3:69210894-69283110 (-)
CBA/J ENSMUSG00210001784
 protein coding gene Chr3:69673521-69746200 (-)
DBA/2J ENSMUSG00185014906
 protein coding gene Chr3:69822600-69895277 (-)
FVB/NJ ENSMUSG00205009346
 protein coding gene Chr3:68707281-68782456 (-)
JF1/MsJ ENSUMUG00000001084
 protein coding gene Chr3:69404240-69475690 (-)
LP/J ENSMUSG00230009413
 protein coding gene Chr3:71833672-71908833 (-)
NOD/ShiLtJ ENSMUSG00190003050
 protein coding gene Chr3:70130976-70205996 (-)
NZO/HlLtJ ENSMUSG00225004495
 protein coding gene Chr3:74534090-74609270 (-)
PWK/PhJ ENSLUMG00010014836
 protein coding gene Chr3:69464424-69535878 (-)
SPRET/EiJ ENSMSPG00010007434
 protein coding gene Chr3:70143573-70215416 (-)
WSB/EiJ ENSIUOG00005016095
 protein coding gene Chr3:70010481-70083125 (-)



Homology
more
  • Human Ortholog
    SI, sucrase-isomaltase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SI, sucrase-isomaltase
  • Links
    NCBI Gene ID: 6476
    UniProt: P14410

  • Chr Location
    3q26.1; chr3:164978898-165090232 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human SI associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 2 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are leaner on a sucrose-containing diet despite normal caloric intake, and show significantly higher plasma acetate levels in response to a sucrose gavage and lower plasma glucose levels in response to a sucrose-tolerance test.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    33
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    751
  • Tissues
    142
  • cDNA Data
    8
  • Literature Summary
    18
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 69983 NCBI Gene Model | MGI Sequence Detail 79307 C57BL/6J ±  kb
    transcript NM_001081137 RefSeq | MGI Sequence Detail 5953 C57BL/6  
    polypeptide B5THE3 UniProt | EBI | MGI Sequence Detail 1818 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      Genomic 2
      cDNA 10
      Primer pair 3
      Antibodies 1

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGD-MRK-14410, MGI:98303
    References
    more
    • Summaries
      All 73
      Developmental Gene Expression 18
      Diseases 1
      Gene Ontology 12
      Phenotypes 15
    • Earliest
      J:8342 James PS, et al., Evidence for a possible regulatory gene (Suc-1) controlling sucrase expression in mouse intestine. Biochem Genet. 1986 Apr;24(3-4):169-81
    • Latest
      J:386605 Aldiss P, et al., Sucrase Isomaltase Dysfunction Reduces Sucrose Intake in Mice and Humans. Gastroenterology. 2025 Mar;168(3):604-607.e3
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory