About   Help   FAQ
Ap5s1 Gene Detail
Summary
  • Symbol
    Ap5s1
  • Name
    adaptor-related protein 5 complex, sigma 1 subunit
  • Synonyms
    0610038L13Rik, 2310035K24Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916846
    NCBI Gene: 69596
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:131052280-131055434 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 63.29 cM, cytoband F3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    179 from dbSNP Build 142
  • Strain Annotations
    13
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916846
 protein coding gene Chr2:131048998-131055434 (+)
129S1/SvImJ ENSMUSG00200046986
 protein coding gene Chr2:128091902-128099099 (+)
A/J ENSMUSG00195026251
 protein coding gene Chr2:128125102-128132319 (+)
AKR/J ENSMUSG00220038513
 protein coding gene Chr2:127885504-127892699 (+)
BALB/cJ ENSMUSG00180044378
 protein coding gene Chr2:127943626-127950837 (+)
C3H/HeJ ENSMUSG00175036448
 protein coding gene Chr2:128476801-128484001 (+)
C57BL/6NJ ENSMUSG00215032445
 protein coding gene Chr2:127973126-127980339 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024325
 protein coding gene Chr2:123998768-124004913 (+)
CAST/EiJ no annotation
CBA/J ENSMUSG00210029470
 protein coding gene Chr2:128333463-128340666 (+)
DBA/2J no annotation
FVB/NJ ENSMUSG00205037376
 protein coding gene Chr2:127148631-127155832 (+)
JF1/MsJ no annotation
LP/J ENSMUSG00230038346
 protein coding gene Chr2:129727068-129734261 (+)
NOD/ShiLtJ ENSMUSG00190014313
 protein coding gene Chr2:128086683-128093870 (+)
NZO/HlLtJ ENSMUSG00225026401
 protein coding gene Chr2:137635890-137643084 (+)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    AP5S1, adaptor related protein complex 5 subunit sigma 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AP5S1, adaptor related protein complex 5 subunit sigma 1
  • Synonyms
    C20orf29
  • Links
    NCBI Gene ID: 55317
    UniProt: Q9NUS5

  • Chr Location
    20p13; chr20:3811384-3828838 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    1
  • Gene trapped
    3
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    2 involving Ap5s1
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
    20 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    6
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    35
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 69596 NCBI Gene Model | MGI Sequence Detail 3155 C57BL/6J ±  kb
transcript NM_001291031 RefSeq | MGI Sequence Detail 1617 C57BL/6  
polypeptide Q9D742 UniProt | EBI | MGI Sequence Detail 170 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 35
    cDNA 35

    Microarray probesets 4
Other
Accession IDs
less
MGI:1917594, MGI:2139290
References
more
  • Summaries
    All 39
    Gene Ontology 6
    Phenotypes 10
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:320005 Hirst J, et al., The fifth adaptor protein complex. PLoS Biol. 2011 Oct;9(10):e1001170
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory