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Nmrk2 Gene Detail
Summary
  • Symbol
    Nmrk2
  • Name
    nicotinamide riboside kinase 2
  • Synonyms
    2310015C21Rik, Itgb1bp3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916814
    NCBI Gene: 69564
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:81034004-81037871 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 39.72 cM, cytoband C1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    173 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916814
 protein coding gene Chr10:81034004-81037885 (-)
129S1/SvImJ ENSMUSG00200043701
 protein coding gene Chr10:77661158-77665039 (-)
A/J ENSMUSG00195048968
 protein coding gene Chr10:78056432-78060313 (-)
AKR/J ENSMUSG00220046664
 protein coding gene Chr10:77654105-77657986 (-)
BALB/cJ ENSMUSG00180052112
 protein coding gene Chr10:78066874-78070757 (-)
C3H/HeJ ENSMUSG00175048697
 protein coding gene Chr10:77937624-77941505 (-)
C57BL/6NJ ENSMUSG00215052251
 protein coding gene Chr10:77679482-77683363 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015625
 protein coding gene Chr10:75197371-75201303 (-)
CAST/EiJ ENSTCUG00005050979
 protein coding gene Chr10:77561128-77565247 (-)
CBA/J ENSMUSG00210048979
 protein coding gene Chr10:77793651-77797532 (-)
DBA/2J ENSMUSG00185046234
 protein coding gene Chr10:78136088-78139969 (-)
FVB/NJ ENSMUSG00205027554
 protein coding gene Chr10:77848888-77852771 (-)
JF1/MsJ ENSUMUG00000018784
 protein coding gene Chr10:79363210-79367124 (-)
LP/J ENSMUSG00230050559
 protein coding gene Chr10:79905670-79909551 (-)
NOD/ShiLtJ ENSMUSG00190042866
 protein coding gene Chr10:78049787-78053668 (-)
NZO/HlLtJ ENSMUSG00225052419
 protein coding gene Chr10:84192242-84196123 (-)
PWK/PhJ ENSLUMG00010044344
 protein coding gene Chr10:77726979-77730903 (-)
SPRET/EiJ ENSMSPG00010031099
 protein coding gene Chr10:79338041-79341399 (-)
WSB/EiJ ENSIUOG00005050017
 protein coding gene Chr10:77789533-77793412 (-)



Homology
more
  • Human Ortholog
    NMRK2, nicotinamide riboside kinase 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NMRK2, nicotinamide riboside kinase 2
  • Synonyms
    ITGB1BP3, MIBP, NRK2
  • Links
    NCBI Gene ID: 27231
    UniProt: Q9NPI5

  • Chr Location
    19p13.3; chr19:3932994-3943081 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit normal protection from FK866-induced neurodegeneration.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • Tissues
    101
  • cDNA Data
    6
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 69564 NCBI Gene Model | MGI Sequence Detail 3868 C57BL/6J ±  kb
    transcript NM_027120 RefSeq | MGI Sequence Detail 1840 C57BL/6  
    polypeptide Q9D7C9 UniProt | EBI | MGI Sequence Detail 195 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 8
      cDNA 6
      Primer pair 2

      Microarray probesets 2
    References
    more
    • Summaries
      All 57
      Developmental Gene Expression 5
      Gene Ontology 11
      Phenotypes 21
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:374738 Zarybnicky T, et al., In vivo modeling of lethal congenital contracture syndrome 1 suggests pathomechanisms in cellular stress responses. FEBS J. 2025;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory