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Tmco2 Gene Detail
Summary
  • Symbol
    Tmco2
  • Name
    transmembrane and coiled-coil domains 2
  • Synonyms
    1700028F16Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916719
    NCBI Gene: 69469
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:120962848-120966414 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 56.80 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    151 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916719
 protein coding gene Chr4:120962848-120966423 (-)
129S1/SvImJ ENSMUSG00200013390
 protein coding gene Chr4:114862786-114866361 (-)
A/J ENSMUSG00195026932
 protein coding gene Chr4:116094623-116098198 (-)
AKR/J ENSMUSG00220021877
 protein coding gene Chr4:115483833-115487408 (-)
BALB/cJ ENSMUSG00180045766
 protein coding gene Chr4:114150642-114154218 (-)
C3H/HeJ ENSMUSG00175024479
 protein coding gene Chr4:115163764-115167339 (-)
C57BL/6NJ ENSMUSG00215034041
 protein coding gene Chr4:116302801-116306377 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026422
 protein coding gene Chr4:111619371-111623591 (-)
CAST/EiJ ENSTCUG00005043400
 protein coding gene Chr4:114977347-114980922 (-)
CBA/J ENSMUSG00210051868
 protein coding gene Chr4:114770207-114773782 (-)
DBA/2J ENSMUSG00185045941
 protein coding gene Chr4:116325237-116328812 (-)
FVB/NJ ENSMUSG00205011369
 protein coding gene Chr4:114252168-114255743 (-)
JF1/MsJ ENSUMUG00000005918
 protein coding gene Chr4:116242715-116246302 (-)
LP/J ENSMUSG00230040703
 protein coding gene Chr4:119681047-119684622 (-)
NOD/ShiLtJ ENSMUSG00190029691
 protein coding gene Chr4:114163593-114167168 (-)
NZO/HlLtJ ENSMUSG00225014375
 protein coding gene Chr4:125233653-125237228 (-)
PWK/PhJ ENSLUMG00010042372
 protein coding gene Chr4:113647837-113651412 (-)
SPRET/EiJ ENSMSPG00010033589
 protein coding gene Chr4:115736187-115739629 (-)
WSB/EiJ ENSIUOG00005044425
 protein coding gene Chr4:114478941-114482516 (-)



Homology
more
  • Human Ortholog
    TMCO2, transmembrane and coiled-coil domains 2
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TMCO2, transmembrane and coiled-coil domains 2
  • Synonyms
    dJ39G22.2
  • Links
    NCBI Gene ID: 127391
    UniProt: Q7Z6W1

  • Chr Location
    1p34.2; chr1:40245947-40251684 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit normal fertility; adult males show no significant changes in relative testis weight, sperm morphology, testis and epididymis histology, or sperm motility parameters.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    3
  • GO References
    3
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 69469 NCBI Gene Model | MGI Sequence Detail 3567 C57BL/6J ±  kb
    transcript NM_001081312 RefSeq | MGI Sequence Detail 710 C57BL/6  
    polypeptide P0C1V4 UniProt | EBI | MGI Sequence Detail 187 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000032341 transmembrane and coiled-coil domain-containing protein 2
      (term hierarchy)
    • InterPro Domains
      IPR031697 Transmembrane and coiled-coil domain-containing protein 2
    Molecular
    Reagents
    less
    • All nucleic 1
      cDNA 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 33
      Gene Ontology 3
      Phenotypes 14
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:385300 Chang HY, et al., Mouse genome engineering uncovers 18 genes dispensable for male reproduction. Andrology. 2026 Mar;14(3):833-846
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory