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Commd10 Gene Detail
Summary
  • Symbol
    Commd10
  • Name
    COMM domain containing 10
  • Synonyms
    2310003A05Rik, DRWMS2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916706
    NCBI Gene: 69456
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:47091917-47242435 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 24.90 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4153 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916706
 protein coding gene Chr18:47091883-47367351 (+)
129S1/SvImJ ENSMUSG00200028111
 protein coding gene Chr18:44109737-44385582 (+)
A/J ENSMUSG00195024818
 protein coding gene Chr18:44288244-44564116 (+)
AKR/J ENSMUSG00220020818
 protein coding gene Chr18:44238106-44513929 (+)
BALB/cJ ENSMUSG00180007493
 protein coding gene Chr18:44781441-45049046 (+)
C3H/HeJ ENSMUSG00175010875
 protein coding gene Chr18:44299367-44566973 (+)
C57BL/6NJ ENSMUSG00215005998
 protein coding gene Chr18:43977243-44252839 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022261
 protein coding gene Chr18:43943494-44069609 (+)
CAST/EiJ ENSTCUG00005013275
 protein coding gene Chr18:43721776-43988393 (+)
CBA/J ENSMUSG00210022423
 protein coding gene Chr18:44351147-44618746 (+)
DBA/2J ENSMUSG00185027027
 protein coding gene Chr18:44251357-44518949 (+)
FVB/NJ ENSMUSG00205014606
 protein coding gene Chr18:43722141-43997987 (+)
JF1/MsJ ENSUMUG00000017353
 protein coding gene Chr18:44271804-44540986 (+)
LP/J ENSMUSG00230027067
 protein coding gene Chr18:46321170-46596986 (+)
NOD/ShiLtJ ENSMUSG00190025472
 protein coding gene Chr18:44022824-44298660 (+)
NZO/HlLtJ ENSMUSG00225026750
 protein coding gene Chr18:46202214-46477518 (+)
PWK/PhJ ENSLUMG00010020984
 protein coding gene Chr18:44383298-44660834 (+)
SPRET/EiJ ENSMSPG00010013019
 protein coding gene Chr18:44552815-44700477 (+)
WSB/EiJ ENSIUOG00005009223
 protein coding gene Chr18:43957434-44224665 (+)



Homology
more
  • Human Ortholog
    COMMD10, COMM domain containing 10
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    COMMD10, COMM domain containing 10
  • Synonyms
    PTD002
  • Links
    NCBI Gene ID: 51397
    UniProt: Q9Y6G5

  • Chr Location
    5q23.1; chr5:116085007-116412762 (+)  GRCh38
Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    7 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    276 phenotypes from multigenic genotypes
    1 images
    762 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit defects in placentation with abnormal trophoblast layer formation and complete lethality throughout fetal growth and development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    3
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    55
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 69456 NCBI Gene Model | MGI Sequence Detail 150519 C57BL/6J ±  kb
    transcript NM_001418808 RefSeq | MGI Sequence Detail 3690 C57BL/6  
    polypeptide Q8JZY2 UniProt | EBI | MGI Sequence Detail 202 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 55
      cDNA 55

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2147306, MGI:2449945
    References
    more
    • Summaries
      All 793
      Diseases 7
      Gene Ontology 3
      Phenotypes 762
    • Earliest
      J:140234 Ogilvy S, et al., Promoter elements of vav drive transgene expression in vivo throughout the hematopoietic compartment. Blood. 1999 Sep 15;94(6):1855-63
    • Latest
      J:391265 Han X, et al., A ketogenesis-ferroptosis axis maintains leukemic stem cell survival and leukemia progression. Cell Stem Cell. 2026 May 11;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory