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Spaca4 Gene Detail
Summary
  • Symbol
    Spaca4
  • Name
    sperm acrosome associated 4
  • Synonyms
    1700008E09Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916613
    NCBI Gene: 69363
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:45374531-45375237 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 29.46 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    108 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916613
 protein coding gene Chr7:45374531-45375240 (-)
129S1/SvImJ ENSMUSG00200026421
 protein coding gene Chr7:32978070-32978776 (-)
A/J ENSMUSG00195043249
 protein coding gene Chr7:37005484-37006190 (-)
AKR/J ENSMUSG00220008560
 protein coding gene Chr7:31303671-31304377 (-)
BALB/cJ ENSMUSG00180031001
 protein coding gene Chr7:33880878-33881584 (-)
C3H/HeJ ENSMUSG00175026795
 protein coding gene Chr7:34413990-34414696 (-)
C57BL/6NJ ENSMUSG00215039260
 protein coding gene Chr7:33667361-33668067 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029742
 protein coding gene Chr7:47675057-47675764 (-)
CAST/EiJ ENSTCUG00005044720
 protein coding gene Chr7:37411696-37412402 (-)
CBA/J ENSMUSG00210040991
 protein coding gene Chr7:34778333-34779039 (-)
DBA/2J ENSMUSG00185037040
 protein coding gene Chr7:38660802-38661508 (-)
FVB/NJ ENSMUSG00205026651
 protein coding gene Chr7:34322913-34323619 (-)
JF1/MsJ ENSUMUG00000039812
 protein coding gene Chr7:43140512-43141218 (-)
LP/J ENSMUSG00230049448
 protein coding gene Chr7:44095115-44095821 (-)
NOD/ShiLtJ ENSMUSG00190049126
 protein coding gene Chr7:34650594-34651300 (-)
NZO/HlLtJ ENSMUSG00225012674
 protein coding gene Chr7:42292480-42293186 (-)
PWK/PhJ ENSLUMG00010046539
 protein coding gene Chr7:33613634-33614340 (-)
SPRET/EiJ ENSMSPG00010031229
 protein coding gene Chr7:33383166-33383872 (-)
WSB/EiJ ENSIUOG00005022284
 protein coding gene Chr7:35198896-35199602 (-)



Homology
more
  • Human Ortholog
    SPACA4, sperm acrosome associated 4
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SPACA4, sperm acrosome associated 4
  • Synonyms
    SAMP14
  • Links
    NCBI Gene ID: 171169
    UniProt: Q8TDM5

  • Chr Location
    19q13.33; chr19:48606742-48607714 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 3 alleles in 3 genetic backgrounds
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for null alleles exhibit reduced male fertility associated with impaired egg binding.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000070563 Ensembl Gene Model | MGI Sequence Detail 707 C57BL/6J ±  kb
    transcript ENSMUST00000094424 Ensembl | MGI Sequence Detail 707 Not Applicable  
    polypeptide ENSMUSP00000091991 Ensembl | MGI Sequence Detail 127 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000015450 sperm acrosome membrane-associated protein 4
      (term hierarchy)
    • InterPro Domains
      IPR016054 Ly-6 antigen/uPA receptor-like
      IPR045860 Snake toxin-like superfamily
      IPR046354 Sperm acrosome membrane-associated protein 4/Protein Bouncer
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 10

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2142173
    References
    more
    • Summaries
      All 30
      Gene Ontology 6
      Phenotypes 5
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory