About   Help   FAQ
Lrrc46 Gene Detail
Summary
  • Symbol
    Lrrc46
  • Name
    leucine rich repeat containing 46
  • Synonyms
    1700006D24Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916547
    NCBI Gene: 69297
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:96925428-96932195 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 60.65 cM, cytoband D
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    288 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916547
 protein coding gene Chr11:96925428-96932233 (-)
129S1/SvImJ ENSMUSG00200052551
 protein coding gene Chr11:94172250-94179057 (-)
A/J ENSMUSG00195051840
 protein coding gene Chr11:93898270-93905069 (-)
AKR/J ENSMUSG00220045389
 protein coding gene Chr11:94157393-94164189 (-)
BALB/cJ ENSMUSG00180049419
 protein coding gene Chr11:94154741-94161547 (-)
C3H/HeJ ENSMUSG00175048539
 protein coding gene Chr11:94152321-94159128 (-)
C57BL/6NJ ENSMUSG00215051985
 protein coding gene Chr11:93743132-93749938 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017045
 protein coding gene Chr11:92805733-92812323 (-)
CAST/EiJ ENSTCUG00005047032
 protein coding gene Chr11:93601952-93608754 (-)
CBA/J ENSMUSG00210053192
 protein coding gene Chr11:93860462-93867260 (-)
DBA/2J ENSMUSG00185045249
 protein coding gene Chr11:94202239-94209045 (-)
FVB/NJ ENSMUSG00205047818
 protein coding gene Chr11:94056983-94063791 (-)
JF1/MsJ ENSUMUG00000028079
 protein coding gene Chr11:94513599-94520395 (-)
LP/J ENSMUSG00230049654
 protein coding gene Chr11:95255230-95262034 (-)
NOD/ShiLtJ ENSMUSG00190050486
 protein coding gene Chr11:94248275-94255071 (-)
NZO/HlLtJ ENSMUSG00225052303
 protein coding gene Chr11:97310458-97317264 (-)
PWK/PhJ ENSLUMG00010043332
 protein coding gene Chr11:94056917-94063729 (-)
SPRET/EiJ ENSMSPG00010048456
 protein coding gene Chr11:94555678-94562384 (-)
WSB/EiJ ENSIUOG00005042209
 protein coding gene Chr11:94002786-94009596 (-)



Homology
more
  • Human Ortholog
    LRRC46, leucine rich repeat containing 46
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LRRC46, leucine rich repeat containing 46
  • Links
    NCBI Gene ID: 90506
    UniProt: Q96FV0

  • Chr Location
    17q21.32; chr17:47831634-47837719 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 2 alleles in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mice for a null allele exhibit male infertility. Males have reduced total sperm counts, impaired sperm motility, and spermiogenesis defects resulting in abnormal sperm flagella and heads.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    645
  • Tissues
    4
  • cDNA Data
    25
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 69297 NCBI Gene Model | MGI Sequence Detail 6768 C57BL/6J ±  kb
    transcript NM_027026 RefSeq | MGI Sequence Detail 1338 Not Specified  
    polypeptide Q9DAP0 UniProt | EBI | MGI Sequence Detail 323 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 25
      cDNA 25

      Microarray probesets 2
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 2
      Gene Ontology 3
      Phenotypes 14
    • Earliest
      J:56548 Zheng B, et al., Engineering a mouse balancer chromosome. Nat Genet. 1999 Aug;22(4):375-8
    • Latest
      J:359010 Zhang XJ, et al., CCDC181 is required for sperm flagellum biogenesis and male fertility in mice. Zool Res. 2024 Sep 18;45(5):1061-1072
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory