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Kctd5 Gene Detail
Summary
  • Symbol
    Kctd5
  • Name
    potassium channel tetramerisation domain containing 5
  • Synonyms
    2610030N08Rik, mKIAA0176
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916509
    NCBI Gene: 69259
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:24266708-24292459 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 12.22 cM, cytoband A3.3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    552 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916509
 protein coding gene Chr17:24266694-24292459 (-)
129S1/SvImJ ENSMUSG00200037573
 protein coding gene Chr17:19699876-19725412 (-)
A/J ENSMUSG00195053806
 protein coding gene Chr17:20718677-20744207 (-)
AKR/J ENSMUSG00220024253
 protein coding gene Chr17:19771719-19797325 (-)
BALB/cJ ENSMUSG00180016088
 protein coding gene Chr17:20001669-20027234 (-)
C3H/HeJ ENSMUSG00175035094
 protein coding gene Chr17:19755295-19780826 (-)
C57BL/6NJ ENSMUSG00215039865
 protein coding gene Chr17:19774643-19800395 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021172
 protein coding gene Chr17:19857319-19882133 (-)
CAST/EiJ ENSTCUG00005047070
 protein coding gene Chr17:20346090-20371698 (-)
CBA/J ENSMUSG00210030079
 protein coding gene Chr17:19594139-19619668 (-)
DBA/2J ENSMUSG00185047142
 protein coding gene Chr17:21807053-21832583 (-)
FVB/NJ ENSMUSG00205020166
 protein coding gene Chr17:20062563-20088110 (-)
JF1/MsJ ENSUMUG00000057260
 protein coding gene Chr17:21266478-21292229 (-)
LP/J ENSMUSG00230054566
 protein coding gene Chr17:23204560-23230090 (-)
NOD/ShiLtJ ENSMUSG00190030048
 protein coding gene Chr17:19695781-19721312 (-)
NZO/HlLtJ ENSMUSG00225050787
 protein coding gene Chr17:25126193-25151723 (-)
PWK/PhJ ENSLUMG00010018603
 protein coding gene Chr17:19175715-19201460 (-)
SPRET/EiJ ENSMSPG00010035866
 protein coding gene Chr17:20507711-20533494 (-)
WSB/EiJ ENSIUOG00005050135
 protein coding gene Chr17:20454308-20479873 (-)



Homology
more
  • Human Ortholog
    KCTD5, potassium channel tetramerization domain containing 5
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KCTD5, potassium channel tetramerization domain containing 5
  • Links
    NCBI Gene ID: 54442
    UniProt: Q9NXV2

  • Chr Location
    16p13.3; chr16:2682521-2709030 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 1 allele in 1 genetic background
    4 images
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit branchial arch defects, enlarged hearts, slight epicardial edema, incomplete embryo turning, placentation defects, and complete lethality during organogenesis. A minority exhibit embryonic growth retardation, abnormal head shape, and incomplete rostral neuropore closure while some have yolk sac vascularization defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    645
  • Tissues
    36
  • cDNA Data
    9
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000016946 Ensembl Gene Model | MGI Sequence Detail 25752 C57BL/6J ±  kb
    transcript ENSMUST00000017090 Ensembl | MGI Sequence Detail 2443 Not Applicable  
    polypeptide ENSMUSP00000017090 Ensembl | MGI Sequence Detail 234 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 9
      Primer pair 1

      Microarray probesets 5
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 4
      Gene Ontology 7
      Phenotypes 11
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:386951 Guertin TM, et al., Onset of embryonic and placental defects coincide in 19 of 22 novel mid-gestation lethal murine knockout lines. Development. 2026 May 15;153(10):dev205276
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory