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Snx5 Gene Detail
Summary
  • Symbol
    Snx5
  • Name
    sorting nexin 5
  • Synonyms
    0910001N05Rik, 1810032P22Rik, D2Ertd52e
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916428
    NCBI Gene: 69178
  • Alliance
    genome feature page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:144092043-144112713 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 70.98 cM, cytoband H1
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    418 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916428
 protein coding gene Chr2:144092043-144112826 (-)
129S1/SvImJ ENSMUSG00200007338
 protein coding gene Chr2:141158213-141180111 (-)
A/J ENSMUSG00195015945
 protein coding gene Chr2:141334894-141356966 (-)
AKR/J ENSMUSG00220037073
 protein coding gene Chr2:140876205-140898278 (-)
BALB/cJ ENSMUSG00180028508
 protein coding gene Chr2:140991033-141013108 (-)
C3H/HeJ ENSMUSG00175031699
 protein coding gene Chr2:141538178-141560252 (-)
C57BL/6NJ ENSMUSG00215018582
 protein coding gene Chr2:141047001-141069077 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024379
 protein coding gene Chr2:136506346-136526277 (-)
CAST/EiJ ENSTCUG00005010647
 protein coding gene Chr2:140193042-140215123 (-)
CBA/J ENSMUSG00210037977
 protein coding gene Chr2:141457418-141479490 (-)
DBA/2J ENSMUSG00185039031
 protein coding gene Chr2:141036534-141058432 (-)
FVB/NJ ENSMUSG00205025183
 protein coding gene Chr2:140214009-140236308 (-)
JF1/MsJ ENSUMUG00000026363
 protein coding gene Chr2:140837344-140859241 (-)
LP/J ENSMUSG00230007087
 protein coding gene Chr2:142740677-142762575 (-)
NOD/ShiLtJ ENSMUSG00190031734
 protein coding gene Chr2:141129664-141151737 (-)
NZO/HlLtJ ENSMUSG00225000918
 protein coding gene Chr2:150728731-150750629 (-)
PWK/PhJ ENSLUMG00010040434
 protein coding gene Chr2:140879842-140901510 (-)
SPRET/EiJ ENSMSPG00010025661
 protein coding gene Chr2:143365394-143387098 (-)
WSB/EiJ ENSIUOG00005022369
 protein coding gene Chr2:140907138-140929218 (-)



Homology
more
  • Human Ortholog
    SNX5, sorting nexin 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SNX5, sorting nexin 5
  • Links
    NCBI Gene ID: 27131
    UniProt: Q9Y5X3

  • Chr Location
    20p11.23; chr20:17941597-17969022 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 2 alleles in 2 genetic backgrounds
    4 images
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele exhibit impaired alveolar epithelial differentiation of type I cells, respiratory failure and lethality during the perinatal and postnatal periods.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    79
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    951
  • Tissues
    88
  • cDNA Data
    27
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 69178 NCBI Gene Model | MGI Sequence Detail 20671 C57BL/6J ±  kb
    transcript NM_001199188 RefSeq | MGI Sequence Detail 2399 ZRU/MplStud  
    polypeptide Q9D8U8 UniProt | EBI | MGI Sequence Detail 404 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 32
      cDNA 31
      Primer pair 1

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGI:1098741, MGI:1915657, MGI:2139178
    References
    more
    • Summaries
      All 63
      Developmental Gene Expression 7
      Gene Ontology 8
      Phenotypes 21
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:391537 Dias BRS, et al., Sorting nexin 5 deficiency impairs MHC class II antigen presentation and inflammatory responses during tuberculosis. J Immunol. 2026 Aug 4;215(8)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory