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Cd209b Gene Detail
Summary
  • Symbol
    Cd209b
  • Name
    CD209b antigen
  • Synonyms
    1810030I22Rik, mSIGNR1, SIGNR1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916415
    NCBI Gene: 69165
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:3967655-3976841 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 1.92 cM, cytoband A1.2-A1.3
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    244 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916415
 protein coding gene Chr8:3967655-3976844 (-)
129S1/SvImJ ENSMUSG00200010015
 protein coding gene Chr8:787291-796521 (-)
A/J ENSMUSG00195008888
 protein coding gene Chr8:1192897-1202083 (-)
AKR/J ENSMUSG00220010437
 protein coding gene Chr8:919456-928642 (-)
BALB/cJ ENSMUSG00180004598
 protein coding gene Chr8:845300-854467 (-)
C3H/HeJ ENSMUSG00175007850
 protein coding gene Chr8:958017-967201 (-)
C57BL/6NJ ENSMUSG00215005470
 protein coding gene Chr8:872373-881557 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030786
 protein coding gene Chr8:765272-774419 (-)
CAST/EiJ ENSTCUG00005018900
 protein coding gene Chr8:883260-892483 (-)
CBA/J ENSMUSG00210010599
 protein coding gene Chr8:835557-844741 (-)
DBA/2J ENSMUSG00185003601
 protein coding gene Chr8:971614-980798 (-)
FVB/NJ ENSMUSG00205005106
 protein coding gene Chr8:905445-914635 (-)
JF1/MsJ ENSUMUG00000028809
 protein coding gene Chr8:924257-933471 (-)
LP/J ENSMUSG00230005736
 protein coding gene Chr8:3141185-3150369 (-)
NOD/ShiLtJ ENSMUSG00190010679
 protein coding gene Chr8:945629-954813 (-)
NZO/HlLtJ ENSMUSG00225015718
 protein coding gene Chr8:10985641-10994836 (-)
PWK/PhJ ENSLUMG00010010291
 protein coding gene Chr8:862989-872197 (-)
SPRET/EiJ ENSMSPG00010016870
 protein coding gene Chr8:827690-835954 (-)
WSB/EiJ ENSIUOG00005004446
 protein coding gene Chr8:859307-868518 (-)



Homology
more
  • Human Ortholog
    CD209, CD209 molecule
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CD209, CD209 molecule
  • Synonyms
    CDSIGN, CLEC4L, DC-SIGN, DC-SIGN1, hDC-SIGN
  • Links
    NCBI Gene ID: 30835
    UniProt: Q9NNX6

  • Chr Location
    19p13.2; chr19:7739993-7747564 (-)  GRCh38
  • Human Ortholog
    CLEC4M, C-type lectin domain family 4 member M
  • Synonyms
    CD209L, CD209L1, CD299, DC-SIGN2, DC-SIGNR, DCSIGNR, HP10347, L-SIGN, LSIGN
  • Links
    NCBI Gene ID: 10332
    UniProt: Q9H2X3

  • Chr Location
    19p13.2; chr19:7763153-7769606 (+)  GRCh38
Human Diseases
more
  • Diseases
    10 with human CD209,CLEC4M associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 2 alleles in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutants are more susceptible to S. pneumoniae infection and fail to clear the bacteria from the circulation. Marginal zone and peritoneal macrophages are impaired in recognizing the bacteria.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    16
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 69165 NCBI Gene Model | MGI Sequence Detail 9187 C57BL/6J ±  kb
    transcript NM_001446749 RefSeq | MGI Sequence Detail 2089 C57BL/6  
    polypeptide Q8CJ91 UniProt | EBI | MGI Sequence Detail 325 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      Genomic 1
      cDNA 16

      Microarray probesets 4
    References
    more
    • Summaries
      All 71
      Developmental Gene Expression 1
      Gene Ontology 9
      Phenotypes 28
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:372130 Yu X, et al., Septal LYVE1(+) macrophages control adipocyte stem cell adipogenic potential. Science. 2025 Aug 28;389(6763):eadg1128
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory