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Hddc3 Gene Detail
Summary
  • Symbol
    Hddc3
  • Name
    HD domain containing 3
  • Synonyms
    1110033O09Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915945
    NCBI Gene: 68695
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:79992852-80000295 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 45.65 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    218 from dbSNP Build 142
  • Strain Annotations
    14
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915945
 protein coding gene Chr7:79992852-80000479 (+)
129S1/SvImJ ENSMUSG00200032917
 protein coding gene Chr7:66811043-66813270 (+)
A/J ENSMUSG00195037161
 protein coding gene Chr7:71223426-71225652 (+)
AKR/J ENSMUSG00220034235
 protein coding gene Chr7:64765439-64767665 (+)
BALB/cJ ENSMUSG00180012687
 protein coding gene Chr7:67948534-67950760 (+)
C3H/HeJ ENSMUSG00175019876
 protein coding gene Chr7:68723135-68725362 (+)
C57BL/6NJ ENSMUSG00215020545
 protein coding gene Chr7:67819012-67826535 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029903
 protein coding gene Chr7:82907348-82913607 (+)
CAST/EiJ no annotation
CBA/J ENSMUSG00210023371
 protein coding gene Chr7:68574365-68576592 (+)
DBA/2J ENSMUSG00185042382
 protein coding gene Chr7:72897165-72899392 (+)
FVB/NJ ENSMUSG00205024526
 protein coding gene Chr7:68456601-68458827 (+)
JF1/MsJ no annotation
LP/J ENSMUSG00230012399
 protein coding gene Chr7:78986646-78988873 (+)
NOD/ShiLtJ ENSMUSG00190017239
 protein coding gene Chr7:68714361-68716588 (+)
NZO/HlLtJ ENSMUSG00225041673
 protein coding gene Chr7:77225494-77227720 (+)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    HDDC3, HD domain containing 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HDDC3, HD domain containing 3
  • Synonyms
    MESH1, MYNRL15, (ppGpp)ase
  • Links
    NCBI Gene ID: 374659
    UniProt: Q8N4P3

  • Chr Location
    15q26.1; chr15:90929968-90935196 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    3
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    718
  • Tissues
    62
  • cDNA Data
    47
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030532 Ensembl Gene Model | MGI Sequence Detail 7444 C57BL/6J ±  kb
    transcript ENSMUST00000032747 Ensembl | MGI Sequence Detail 1510 Not Applicable  
    polypeptide ENSMUSP00000032747 Ensembl | MGI Sequence Detail 179 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 47
      cDNA 47
      Antibodies 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:2142367
    References
    more
    • Summaries
      All 50
      Developmental Gene Expression 5
      Gene Ontology 3
      Phenotypes 21
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory